Transcription Factor
| Accessions: | SPIB_DBD (HumanTF 1.0), SPIB_TF1 (HumanTF2 1.0), SPIB_TF2 (HumanTF2 1.0) |
| Names: | SPIB, SPIB_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q01892 |
| Notes: | Ensembl ID: ENSG00000142539; DNA-binding domain sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000142539; Construct type: TF1(SBP); TF family: ETS; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000142539; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 115 |
| Pfam Domains: | 22-106 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAEALVAGPEGKGSEAGTRKKLRLYQFLLGLLTRGDMRECVWWVEPGAGVFQFSSKHKEL 60 61 LARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAVRRA |
| Interface Residues: | 78, 79, 81, 82, 83, 85, 86, 95, 98, 99 |
| 3D-footprint Homologues: | 7jsa_J, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 8ee9_F, 1dux_F, 5cl8_A, 3zp5_A, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 7uin_D |
| Binding Motifs: | SPIB_DBD aAAAAGmGGAAGTr TEAD4_SPIB_1 rGAATGCGGAAGTd TEAD4_SPIB_2 GGAATGCGGAAGTd |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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