Transcription Factor

						

			
Accessions: 4nqa_B (3D-footprint 20231221)

			
Names: Liver X nuclear receptor beta, Liver X receptor beta, NR1H2_HUMAN, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: F1D8P7
Length: 369
Pfam Domains:     13-82 Zinc finger, C4 type (two domains)
  168-351 Ligand-binding domain of nuclear hormone receptor
Sequence: 
(in bold interface residues)		   1 KKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQM   60
  61 DAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSS  120
 121 QGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFA  180
 181 HFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF  240
 241 LKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEP  300
 301 GRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKL  360
 361 PPLLSEIWD
Interface Residues: 22, 23, 25, 26, 32, 33, 35, 36, 39, 40, 66, 94, 96, 98, 101
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: 4nqa_AB AGGTnAnnnnAGGTCA
Binding Sites: 4nqa_E
4nqa_F
			
Publications: Lou X, Toresson G, Benod C, Suh J.H, Philips K.J, Webb P, Gustafsson J.A. Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA. Nature structural & molecular biology 21:277-81 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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