Transcription Factor

Accessions: 4nqa_B (3D-footprint 20231221)
Names: Liver X nuclear receptor beta, Liver X receptor beta, NR1H2_HUMAN, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: F1D8P7
Length: 369
Pfam Domains: 13-82 Zinc finger, C4 type (two domains)
168-351 Ligand-binding domain of nuclear hormone receptor
Sequence:
(in bold interface residues)
1 KKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQM 60
61 DAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSS 120
121 QGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFA 180
181 HFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF 240
241 LKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEP 300
301 GRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKL 360
361 PPLLSEIWD
Interface Residues: 22, 23, 25, 26, 32, 33, 35, 36, 39, 40, 66, 94, 96, 98, 101
3D-footprint Homologues: 6fbq_A, 6l6q_B, 7wnh_D, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B
Binding Motifs: 4nqa_AB AGGTnAnnnnAGGTCA
Binding Sites: 4nqa_E
4nqa_F
Publications: Lou X, Toresson G, Benod C, Suh J.H, Philips K.J, Webb P, Gustafsson J.A. Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA. Nature structural & molecular biology 21:277-81 (2014). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.