Transcription Factor
| Accessions: | T161902_1.02 (CISBP 1.02), P0CE41 (JASPAR 2024) |
| Names: | HAP1, T161902_1.02;, CYP1 activatory protein, HAP1_YEAST, Heme activator protein 1, Heme-responsive zinc finger transcription factor HAP1 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Zinc cluster |
| Length: | 1502 |
| Pfam Domains: | 63-96 Fungal Zn(2)-Cys(6) binuclear cluster domain |
| Sequence: (in bold interface residues) | 1 MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRI 60 61 PLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRER 120 121 VKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQ 180 181 QQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWL 240 241 SIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKC 300 301 PVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMM 360 361 PPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDH 420 421 SSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRV 480 481 IALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPIT 540 541 QINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSM 600 601 AKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDL 660 661 TTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSN 720 721 NGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKI 780 781 WYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQID 840 841 LCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGG 900 901 SVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKH 960 961 MTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNT 1020 1021 NSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVE 1080 1081 DEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMN 1140 1141 KSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDAL 1200 1201 GFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAK 1260 1261 RRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITS 1320 1321 QMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMN 1380 1381 GAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLV 1440 1441 EVVGGYNDPNNLGRNDAVDFLPVDNVEIDGVGIKINYHLLTSIYVTSILSYTVLEDDAND 1500 1501 EK |
| Interface Residues: | 59, 70, 71, 72, 73, 75, 76, 107 |
| 3D-footprint Homologues: | 6o19_A, 1pyi_A, 2er8_C, 1hwt_C, 3coq_A, 6gys_C, 7uik_T, 1zme_D, 1d66_B, 7n5w_A, 8h9h_G, 7eyi_G |
| Binding Motifs: | M1810_1.02 wawstCCGr MA0312.1 CGGAswTa MA0312.2 dgCCGATAwa MA0312.3 CCGATAwa |
| Binding Sites: | MA0312.3.12 / MA0312.3.9 MA0312.2.1 MA0312.2.10 MA0312.2.11 MA0312.2.12 MA0312.2.13 MA0312.2.14 MA0312.2.15 / MA0312.2.3 MA0312.2.16 MA0312.2.17 MA0312.2.18 MA0312.2.19 MA0312.2.2 MA0312.2.20 MA0312.2.4 MA0312.2.5 MA0312.2.6 MA0312.2.7 MA0312.2.8 MA0312.2.9 MA0312.3.1 / MA0312.3.19 MA0312.3.10 MA0312.3.11 / MA0312.3.8 MA0312.3.13 / MA0312.3.14 / MA0312.3.15 / MA0312.3.16 / MA0312.3.18 / MA0312.3.20 / MA0312.3.3 MA0312.3.17 / MA0312.3.4 MA0312.3.2 MA0312.3.5 / MA0312.3.6 / MA0312.3.7 |
| Publications: | Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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