Transcription Factor

						

			
Accessions: 5iyd_M (3D-footprint 20231221)

			
Names: EC 2.3.1.48, General transcription factor TFIIB, S300-II, TF2B_HUMAN, Transcription initiation factor IIB
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q00403
Length: 310
Pfam Domains:      8-49 TFIIB zinc-binding
   93-197 Cyclin, N-terminal domain
  115-185 Transcription factor TFIIB repeat
  209-279 Transcription factor TFIIB repeat
Sequence: 
(in bold interface residues)		   1 LDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSR   60
  61 VGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMAD  120
 121 RINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRI  180
 181 SKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVP  240
 241 GRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKF  300
 301 DTPVDKLPQL
Interface Residues: 59, 70, 71, 75, 103, 146, 277, 280
3D-footprint Homologues: 3f27_D, 6cnb_R, 6eu0_Z, 1c9b_M
Binding Motifs: 5iyd_M TTTTnttnTTTnntT
Binding Sites: 5iyd_X
5iyd_Y
			
Publications: He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E. Near-atomic resolution visualization of human transcription promoter opening. Nature 533:359-65 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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