Transcription Factor
| Accessions: | br-Z1 (DrosophilaTF 1.1), T000288_1.02 (CISBP 1.02), Q01295 (JASPAR 2024) |
| Names: | BRC1_DROME, T000288_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2, JASPAR 2024 3 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:ABF1,C2H2 ZF |
| Length: | 727 |
| Pfam Domains: | 22-121 BTB/POZ domain 636-659 C2H2-type zinc finger 668-685 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFREL 60 61 LKSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQA 120 121 EDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAV 180 181 PSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPD 240 241 LPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGN 300 301 GISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSG 360 361 DGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQL 420 421 QQSGDLAVSPQGKLTTNATTTTTTINNSITNNNNNNNNNNYDYSLPTKNSNSQKTPSPTT 480 481 TTLTTPTTTTPTRPTAITSASGICGLNLSTFAANGSSSGGSNGGLSMTALLPQQQQQQQQ 540 541 QHQMSQQQQQQQQQQQQQGNSSSGQQQQPNGILACSTPKANTPTTTQQQMYAAVMAAAAS 600 601 ASASTSGSANSSLNNSNSTLNTSGGLNNSASGGDDFRCNPCNKNLSSLTRLKRHIQNVHM 660 661 RPTKEPVCNICKRVYSSLNSLRNHKSIYHRNLKQPKQEPGVGATQAAANSFYHQQHQQQQ 720 721 LNHHSSS |
| Interface Residues: | 646, 647, 648, 649, 650, 651, 652, 653, 657, 658, 676, 677, 678, 679, 680, 682, 683 |
| 3D-footprint Homologues: | 7ysf_A, 1g2f_F, 8cuc_F, 6ml4_A, 6u9q_A, 2drp_D, 5yel_A, 6e94_A, 4x9j_A, 1llm_D, 5v3j_F, 2lt7_A |
| Binding Motifs: | br-Z1 TAAwwrACAArw M2533_1.02 wwrtaAwwrACAArwcwm MA0010.1 rtaAwwrACAArwc MA0011.1 wwCTAtTt MA0012.1 wAAACwArwhs MA0010.2 taAwwrACAArw MA0011.2 CTAtTt MA0012.2 wAAACwAr |
| Binding Sites: | MA0012.2.8 MA0010.1.1 MA0010.1.2 MA0010.1.3 MA0010.1.4 MA0010.1.5 MA0010.1.6 MA0010.1.7 MA0010.1.8 MA0010.1.9 MA0011.1.1 MA0011.1.10 MA0011.1.11 MA0011.1.12 MA0011.1.2 MA0011.1.3 MA0011.1.4 MA0011.1.5 MA0011.1.6 MA0011.1.7 MA0011.1.8 MA0011.1.9 MA0012.1.1 MA0012.1.10 MA0012.1.11 MA0012.1.12 MA0012.1.2 MA0012.1.3 MA0012.1.4 MA0012.1.5 MA0012.1.6 MA0012.1.7 MA0012.1.8 MA0012.1.9 MA0010.2.1 MA0010.2.2 / MA0010.2.6 MA0010.2.3 MA0010.2.4 MA0010.2.5 MA0010.2.7 MA0010.2.8 MA0010.2.9 MA0011.2.1 MA0011.2.10 MA0011.2.11 / MA0011.2.12 MA0011.2.2 MA0011.2.3 MA0011.2.4 MA0011.2.5 MA0011.2.6 MA0011.2.7 MA0011.2.8 MA0011.2.9 MA0012.2.1 MA0012.2.10 MA0012.2.11 MA0012.2.12 MA0012.2.2 MA0012.2.3 MA0012.2.4 / MA0012.2.7 MA0012.2.5 MA0012.2.6 MA0012.2.9 |
| Publications: | von Kalm L., Crossgrove K., Von Seggern D., Guild G. M., Beckendorf S. K. The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J. 13:3505-3516 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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