Transcription Factor
| Accessions: | FOXA2_HUMAN (HOCOMOCO 10), Q9Y261 (JASPAR 2024) |
| Names: | Forkhead box protein A2, FOXA2_HUMAN, Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, TCF-3B, Transcription factor 3B |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 457 |
| Pfam Domains: | 17-158 Forkhead N-terminal region 159-254 Fork head domain 373-446 HNF3 C-terminal domain |
| Sequence: (in bold interface residues) | 1 MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGSGSGNMSA 60 61 GSMNMSSYVGAGMSPSLAGMSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGGQAAGA 120 121 MGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKML 180 181 TLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSG 240 241 NMFENGCYLRRQKRFKCEKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAAGPASETPAG 300 301 TESPHSSASPCQEHKRGGLGELKGTPAAALSPPEPAPSPGQQQQAAAHLLGPPHHPGLPP 360 361 EAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGYGSPMPG 420 421 SLAMGPVTNKTGLDASPLAADTSYYQGVYSRPIMNSS |
| Interface Residues: | 149, 151, 153, 154, 156, 202, 204, 205, 206, 208, 209, 210, 212, 213, 222, 229, 254 |
| 3D-footprint Homologues: | 7yz7_A, 7yzb_A, 7vox_H, 2hdc_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 3l2c_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 3qrf_G |
| Binding Motifs: | FOXA2_HUMAN.H10MO.A|M01143 TGTTTRCwywg MA0047.3 awGTAAACAww MA0047.4 wGTAAACA |
| Binding Sites: | MA0047.4.17 / MA0047.4.19 MA0047.4.14 MA0047.4.15 MA0047.4.8 MA0047.4.4 / MA0047.4.9 MA0047.4.1 MA0047.4.7 MA0047.4.3 MA0047.4.2 / MA0047.4.5 / MA0047.4.6 MA0047.3.1 MA0047.3.10 / MA0047.3.11 MA0047.3.11 MA0047.3.12 MA0047.3.13 MA0047.3.14 MA0047.3.15 MA0047.3.16 MA0047.3.17 MA0047.3.18 MA0047.3.19 MA0047.3.2 MA0047.3.20 MA0047.3.2 / MA0047.3.3 MA0047.3.4 MA0047.3.5 MA0047.3.6 MA0047.3.7 / MA0047.3.8 MA0047.3.8 / MA0047.3.9 MA0047.3.10 / MA0047.3.9 MA0047.3.19 MA0047.3.20 MA0047.3.3 MA0047.3.7 MA0047.4.10 / MA0047.4.18 MA0047.4.11 MA0047.4.12 MA0047.4.13 MA0047.4.16 MA0047.4.20 |
| Publications: | Li J, Dantas Machado AC, Guo M, Sagendorf JM, Zhou Z, Jiang L, Chen X, Wu D, Qu L, Chen Z, Chen L, Rohs R, Chen Y. Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site. Biochemistry 56:3745-3753 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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