Transcription Factor
| Accessions: | O08900 (JASPAR 2024) |
| Names: | Ikaros family zinc finger protein 3, IKZF3_MOUSE, Zinc finger protein Aiolos |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O08900 |
| Length: | 507 |
| Pfam Domains: | 132-155 Zinc-finger double domain 145-167 C2H2-type zinc finger 145-167 Zinc finger, C2H2 type 159-181 Zinc-finger double domain 173-195 C2H2-type zinc finger 188-211 Zinc-finger double domain 201-223 Zinc finger, C2H2 type 201-223 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MEDIQPTVELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSREAPANEDEDAGEDSMKV 60 61 KDEYSDRDENIMKPEPMGDAEESEMPYSYAREYSDYESIKLERHVPYDNSRPTGGKMNCD 120 121 VCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNY 180 181 ACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRAFLQNPDLGDAASVEA 240 241 RHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDANYNPGYMYEKENEMMQT 300 301 RMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSVYPIALTRADMPNGAPQEMEK 360 361 KRILLPEKILPSERGLSPNNSAQDSTDTDSNHEDRQHLYQQSHVVLPQARNGMPLLKEVP 420 421 RSFELLKPPPICLRDSIKVINKEGEVMDVFRCDHCHVLFLDYVMFTIHMGCHGFRDPFEC 480 481 NMCGYRSHDRYEFSSHIARGEHRAMLK |
| Interface Residues: | 127, 128, 129, 130, 131, 133, 134, 135, 136, 137, 140, 142, 155, 156, 157, 158, 159, 160, 161, 162, 163, 166, 183, 184, 185, 186, 187, 188, 189, 190, 191, 193, 194, 212, 213, 214, 215, 216, 217, 218 |
| 3D-footprint Homologues: | 8cuc_F, 7y3l_A, 5k5i_A, 2kmk_A, 8ssq_A, 7w1m_H, 8ssu_A, 6ml4_A, 5v3j_F, 2i13_A, 6blw_A, 5kkq_D, 5yel_A, 5ei9_F, 4m9v_C, 6e94_A, 7ysf_A, 6wmi_A, 7y3m_I, 2jpa_A, 1ubd_C, 1yuj_A, 3uk3_C, 6jnm_A, 7n5w_A, 7txc_E, 5kl3_A, 2drp_D, 1g2f_F, 5yj3_D, 5und_A, 2gli_A, 7eyi_G, 4x9j_A, 1mey_C, 2wbs_A, 1f2i_J, 6u9q_A, 8h9h_G, 1tf3_A, 1tf6_A, 2lt7_A, 6a57_A, 1llm_D, 5k5l_F, 8gn3_A |
| Binding Motifs: | MA1992.1 rsrCAGGAAGTGggg MA1992.2 CAGGAAGTG |
| Binding Sites: | MA1992.1.1 MA1992.1.10 / MA1992.1.15 MA1992.1.11 / MA1992.1.20 MA1992.1.12 MA1992.1.13 MA1992.1.14 MA1992.1.15 MA1992.1.16 MA1992.1.17 MA1992.1.18 MA1992.1.19 MA1992.1.2 MA1992.1.20 MA1992.1.3 MA1992.1.4 MA1992.1.5 / MA1992.1.6 MA1992.1.6 / MA1992.1.8 MA1992.1.10 / MA1992.1.7 MA1992.1.11 / MA1992.1.8 MA1992.1.13 / MA1992.1.9 MA1992.2.15 MA1992.2.10 MA1992.2.16 MA1992.2.8 MA1992.2.18 MA1992.1.12 MA1992.1.14 MA1992.1.16 MA1992.1.17 MA1992.1.18 MA1992.1.19 MA1992.1.5 MA1992.1.7 MA1992.1.9 MA1992.2.1 MA1992.2.11 / MA1992.2.17 MA1992.2.12 / MA1992.2.20 / MA1992.2.3 / MA1992.2.5 MA1992.2.13 MA1992.2.14 MA1992.2.19 MA1992.2.2 MA1992.2.4 MA1992.2.6 MA1992.2.7 MA1992.2.9 |
| Publications: | Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev 30:1971-90 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.