Transcription Factor
| Accessions: | HOXA1_Full (HumanTF2 1.0) |
| Names: | Homeobox protein Hox-1F, Homeobox protein Hox-A1, HOXA1, HXA1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P49639 |
| Notes: | Ensembl ID: ENSG00000105991; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 336 |
| Pfam Domains: | 233-286 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQ 60 61 IGSPHHHHHHHHRHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVS 120 121 GGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSL 180 181 SPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQ 240 241 LTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATP 300 301 PGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTSH* |
| Interface Residues: | 231, 233, 234, 235, 271, 272, 274, 275, 278, 279, 282, 283, 286 |
| 3D-footprint Homologues: | 2lkx_A, 1zq3_P, 1fjl_B, 5zjt_E, 3a01_E, 2h1k_B, 7psx_B, 1b72_A, 5hod_A, 3lnq_A, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1jgg_B, 6es3_K, 4xrs_G, 3d1n_M, 2hos_A, 5zfz_A, 4cyc_A, 6m3d_C, 5flv_I, 2ld5_A, 1nk2_P, 4j19_B, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1au7_A, 1o4x_A, 8g87_X, 4qtr_D, 1mnm_C, 1du0_A, 1k61_B, 3l1p_A |
| Binding Motifs: | ELK1_HOXA1_1 aCCGGAAGTAAtTa ELK1_HOXA1_2 rCCGGAAGTvaTya PBX4_HOXA1 vymATmAATCA- |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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