Transcription Factor
| Accessions: | CDX2_HUMAN (HOCOMOCO 10), Q99626 (JASPAR 2024) |
| Names: | Caudal-type homeobox protein 2, CDX-3, CDX2_HUMAN, Homeobox protein CDX-2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q99626 |
| Length: | 313 |
| Pfam Domains: | 13-179 Caudal like protein activation region 188-243 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQS 60 61 PGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPH 120 121 HHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQ 180 181 VKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAK 240 241 ERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVL 300 301 GPTGGVLNPTVTQ |
| Interface Residues: | 182, 184, 187, 188, 189, 190, 228, 229, 231, 232, 235, 236, 239, 240, 243 |
| 3D-footprint Homologues: | 2lkx_A, 1puf_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 2ld5_A, 6es3_K, 7q3o_C, 1ig7_A, 4xrs_G, 3a01_E, 2h1k_B, 5zfz_A, 3rkq_B, 6m3d_C, 5flv_I, 3cmy_A, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 7psx_B, 2hos_A, 1fjl_B, 6a8r_A, 5jlw_D, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 1mnm_C, 8g87_X, 1puf_B, 1k61_B, 5hod_A, 3l1p_A, 4qtr_D, 1b72_A |
| Binding Motifs: | MA0465.1 rdGymATAAAa CDX2_HUMAN.H10MO.C|M01047 wTTTAyrr MA0465.2 adGCAATAAAaw MA0465.3 GCAATAAA |
| Binding Sites: | MA0465.3.5 MA0465.3.7 MA0465.3.16 / MA0465.3.6 MA0465.3.19 / MA0465.3.2 / MA0465.3.20 / MA0465.3.8 MA0465.3.13 / MA0465.3.15 / MA0465.3.4 MA0465.3.14 / MA0465.3.17 MA0465.3.9 MA0465.1.1 MA0465.1.10 MA0465.1.11 MA0465.1.12 MA0465.1.13 MA0465.1.14 MA0465.1.15 MA0465.1.16 MA0465.1.17 MA0465.1.18 MA0465.1.19 MA0465.1.2 MA0465.1.20 MA0465.1.3 MA0465.1.4 MA0465.1.5 MA0465.1.6 MA0465.1.7 MA0465.1.8 MA0465.1.9 MA0465.2.1 MA0465.2.10 MA0465.2.11 / MA0465.2.7 MA0465.2.12 / MA0465.2.8 MA0465.2.13 / MA0465.2.9 MA0465.2.10 / MA0465.2.14 MA0465.2.12 / MA0465.2.15 MA0465.2.16 MA0465.2.13 / MA0465.2.17 MA0465.2.14 / MA0465.2.18 MA0465.2.15 / MA0465.2.19 MA0465.2.1 / MA0465.2.2 MA0465.2.16 / MA0465.2.20 MA0465.2.3 MA0465.2.2 / MA0465.2.4 MA0465.2.4 / MA0465.2.5 MA0465.2.6 MA0465.2.7 MA0465.2.5 / MA0465.2.8 MA0465.2.6 / MA0465.2.9 MA0465.2.11 MA0465.2.17 MA0465.2.18 MA0465.2.19 MA0465.2.20 MA0465.2.3 MA0465.3.1 MA0465.3.10 / MA0465.3.11 MA0465.3.12 MA0465.3.18 MA0465.3.3 |
| Publications: | Verzi M.P, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch J.P, Dang D.T, Brown M, Clevers H, Liu X.S, Shivdasani R.A. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America 107:15157-62 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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