Transcription Factor
| Accessions: | UP00619B (UniPROBE 20160601) |
| Names: | homeobox protein prophet of Pit-1, Pituitary-specific homeodomain factor, PROP-1, PROP1_R112Q |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein prophet of Pit-1: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-st |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain 38-67 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 FSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEAMIQV 60 61 WFQNRRAKQRKQERSLLQPLAHLSPA |
| Interface Residues: | 14, 15, 16, 17, 18, 20, 49, 56, 57, 59, 60, 63, 64, 67, 68, 71, 74, 75 |
| 3D-footprint Homologues: | 4j19_B, 3cmy_A, 1ig7_A, 2h1k_B, 6a8r_A, 3d1n_M, 1puf_A, 1mnm_C, 5zfz_A, 1fjl_B, 1jgg_B, 1b01_B, 1nk2_P, 6m3d_C, 3lnq_A, 2lkx_A, 1zq3_P, 1le8_B, 7q3o_C, 6es3_K, 2ld5_A, 1k61_B, 5zjt_E, 1b72_A, 2hos_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 5jlw_D, 1au7_A, 4cyc_A, 2h8r_B, 4xrs_G, 3l1p_A, 1puf_B, 3a01_E, 2hdd_A, 5flv_I, 2ky8_A, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 4qtr_D, 1o4x_A, 1du0_A, 4xrm_B, 8g87_X |
| Binding Motifs: | UP00619B_1 rwrtdTwwtyyAATTArkwywaw |
| Binding Sites: | AATTAATT ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATAATTGG ATCAATTA ATTAATTA ATTAATTG CAATTAGC CCAATTAG CCTAATTA CTAATTAA CTAATTAG GATAATTA GCTAATTA TAATTAGA TTAATTAA AATTAGCT |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.