Transcription Factor
| Accessions: | OTX1_DBD (HumanTF 1.0), OTX1 (HT-SELEX2 May2017) |
| Names: | Homeobox protein OTX1, Orthodenticle homolog 1, OTX1, OTX1_HUMAN, ENSG00000115507 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P32242 |
| Notes: | Ensembl ID: ENSG00000115507; DNA-binding domain sequence; TF family: homeodomain; Clone source: MGC, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 117 |
| Pfam Domains: | 30-86 Homeobox domain |
| Sequence: (in bold interface residues) | 1 YGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMRE 60 61 EVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQ |
| Interface Residues: | 8, 12, 30, 31, 32, 33, 71, 72, 74, 75, 78, 79, 81, 82, 83, 86 |
| 3D-footprint Homologues: | 1e3o_C, 8ejp_B, 1fjl_B, 6a8r_A, 1ig7_A, 3cmy_A, 8pmf_A, 5zfz_A, 2r5y_A, 1puf_A, 3d1n_M, 3lnq_A, 1nk2_P, 1zq3_P, 2lkx_A, 1jgg_B, 6m3d_C, 2ld5_A, 7psx_B, 1au7_A, 5hod_A, 3a01_E, 8osb_E, 7q3o_C, 1b72_A, 5jlw_D, 3rkq_B, 8eml_B, 6es3_K, 4xrs_G, 2hdd_A, 4cyc_A, 5flv_I, 2hos_A, 9b8u_A, 5zjt_E, 4j19_B, 1puf_B, 8ik5_C, 1le8_A, 7xrc_C, 2xsd_C, 1k61_B, 4qtr_D, 1o4x_A, 1le8_B, 1du0_A, 8g87_X, 1mnm_C, 8bx1_A |
| Binding Motifs: | OTX1_DBD_1 swTAATCCGmTTAwm OTX1_DBD_2 yTAATCcs OTX1_2 mTAATCCs OTX1_4 yTAATCCsyt OTX1_methyl_1 cTAATCCc OTX1_methyl_3 yTAATCCyyy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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