Transcription Factor
| Accessions: | UP00129A (UniPROBE 20160601) |
| Names: | class 3, Oct-6, Oct6, Octamer-binding transcription factor 6, Otf-6, Otf6, POU domain, POU-domain transcription factor SCIP, Pou3f1, Test1, transcription factor 1, Tst-1, Tst1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P21952 |
| Description: | POU domain, class 3, transcription factor 1 |
| Length: | 185 |
| Pfam Domains: | 17-90 Pou domain - N-terminal to homeobox domain 109-165 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQT 60 61 TICRFEALQLSFKNMCKLKPLLNKWLEETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVK 120 121 GALESHFLKCPKPSAHEITGLADSLQLEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDV 180 181 YAPGE |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 70, 74, 109, 110, 111, 112, 150, 151, 153, 154, 157, 158, 161, 162, 165 |
| 3D-footprint Homologues: | 3d1n_M, 3l1p_A, 7u0g_M, 7xrc_C, 1e3o_C, 8g87_X, 1au7_A, 2xsd_C, 1o4x_A, 3cmy_A, 5zfz_A, 2h1k_B, 1fjl_B, 6a8r_A, 1puf_A, 1ig7_A, 1zq3_P, 1jgg_B, 1nk2_P, 2lkx_A, 4xrs_G, 3rkq_B, 2r5y_A, 7psx_B, 5hod_A, 1b72_A, 3a01_E, 2ld5_A, 5jlw_D, 7q3o_C, 1le8_A, 1mnm_C, 1du0_A, 6es3_K, 5flv_I, 1k61_B, 5zjt_E, 4cyc_A, 4qtr_D, 3lnq_A |
| Binding Motifs: | UP00129A_1 rmyTAATTAATTAaktm |
| Binding Sites: | ATGCAAAT AATAATTA ACTAATTA ATAATGAG ATAATTAA ATAATTAG ATTAATTA ATTATGCA ATTATGCG CATAATTA CCTAATTA CCTCATTA CTAATTAA CTAATTAG CTCATTAA CTTAATTA GCTAATTA GTTAATTA TAATTAAA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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