Transcription Factor
| Accessions: | ZKSC1_HUMAN (HOCOMOCO 10), P17029 (JASPAR 2024) |
| Names: | Zinc finger protein 139, Zinc finger protein 36, Zinc finger protein KOX18, Zinc finger protein with KRAB and SCAN domains 1, ZKSC1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P17029 |
| Length: | 563 |
| Pfam Domains: | 51-140 SCAN domain 227-262 KRAB box 377-396 C2H2-type zinc finger 377-399 C2H2-type zinc finger 377-399 Zinc finger, C2H2 type 392-415 Zinc-finger double domain 404-415 C2H2-type zinc finger 405-427 C2H2-type zinc finger 405-427 Zinc finger, C2H2 type 419-444 Zinc-finger double domain 432-453 C2H2-type zinc finger 433-455 Zinc finger, C2H2 type 433-455 C2H2-type zinc finger 448-471 Zinc-finger double domain 460-481 C2H2-type zinc finger 461-483 Zinc finger, C2H2 type 461-483 C2H2-type zinc finger 475-499 Zinc-finger double domain 488-503 C2H2-type zinc finger 489-511 Zinc finger, C2H2 type 489-511 C2H2-type zinc finger 507-528 Zinc-finger double domain 516-531 C2H2-type zinc finger 517-535 C2H2-type zinc finger 517-539 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSTLQDTPPPDPEIFRQRFR 60 61 RFCYQNTFGPREALSRLKELCHQWLRPEINTKEQILELLVLEQFLSILPKELQVWLQEYR 120 121 PDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLHHEATQSHF 180 181 KHSSRKPRLLQSRALPAAHIPAPPHEGSPRDQAMASALFTADSQAMVKIEDMAVSLILEE 240 241 WGCQNLARRNLSRDNRQENYGSAFPQGGENRNENEESTSKAETSEDSASRGETTGRSQKE 300 301 FGEKRDQEGKTGERQQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSL 360 361 SSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNL 420 421 VLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQ 480 481 RIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHA 540 541 RERASEYSPASLDAFGAFLKSCV |
| Interface Residues: | 388, 389, 390, 391, 393, 394, 397, 415, 416, 417, 418, 419, 422, 443, 444, 445, 446, 447, 449, 450, 452, 453, 454, 456, 471, 472, 473, 474, 475, 477, 478, 479, 481, 499, 500, 501, 502, 503, 504, 505, 506, 507, 527, 528, 529, 530, 531, 533, 534 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 8ssq_A, 7w1m_H, 2kmk_A, 2drp_D, 8ssu_A, 5kkq_D, 8gn3_A, 5yel_A, 1tf3_A, 7n5w_A, 6jnm_A, 5ei9_F, 1g2f_F, 6ml4_A, 5k5i_A, 2gli_A, 1tf6_A, 8h9h_G, 7y3m_I, 8cuc_F, 7y3l_A, 7txc_E, 6blw_A, 6u9q_A, 7ysf_A, 6e94_A, 2lt7_A, 6a57_A, 2jpa_A, 1llm_D, 5yj3_D, 4x9j_A, 1f2i_J, 5kl3_A, 2wbs_A, 4m9v_C, 3uk3_C |
| Binding Motifs: | ZKSC1_HUMAN.H10MO.C|M01620 ccygGCACAyAGTAGGtsctca MA1585.1 AyAGTAGGtg MA1585.2 AyAGTAGGt |
| Binding Sites: | MA1585.1.1 / MA1585.1.2 MA1585.1.10 / MA1585.1.11 MA1585.1.11 / MA1585.1.12 / MA1585.1.13 / MA1585.1.3 / MA1585.1.4 MA1585.1.13 / MA1585.1.14 MA1585.1.14 / MA1585.1.15 MA1585.1.15 / MA1585.1.17 / MA1585.1.6 / MA1585.1.7 MA1585.1.16 / MA1585.1.18 MA1585.1.17 / MA1585.1.19 MA1585.1.18 / MA1585.1.20 MA1585.1.19 MA1585.1.2 / MA1585.1.3 MA1585.1.20 MA1585.1.4 / MA1585.1.5 MA1585.1.5 / MA1585.1.6 MA1585.1.7 / MA1585.1.8 MA1585.1.8 / MA1585.1.9 MA1585.1.10 / MA1585.1.9 MA1585.1.1 MA1585.1.16 MA1585.2.1 MA1585.2.10 / MA1585.2.6 MA1585.2.11 / MA1585.2.12 / MA1585.2.13 / MA1585.2.4 MA1585.2.14 / MA1585.2.15 / MA1585.2.18 / MA1585.2.3 / MA1585.2.7 / MA1585.2.8 MA1585.2.16 / MA1585.2.2 MA1585.2.17 MA1585.2.19 MA1585.2.20 / MA1585.2.5 MA1585.2.9 |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.