Transcription Factor
Accessions: | 2pub_A (3D-footprint 20231221), 2puc_A (3D-footprint 20231221), 2pud_A (3D-footprint 20231221) |
Names: | HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR, PURR_ECOLI |
Organisms: | Escherichia coli, strain K12 |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P0ACP7 |
Length: | 338 |
Pfam Domains: | 1-46 Bacterial regulatory proteins, lacI family 58-323 Periplasmic binding proteins and sugar binding domain of LacI family 60-306 Periplasmic binding protein domain 169-329 Periplasmic binding protein-like domain |
Sequence: (in bold interface residues) | 1 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSI 60 61 GLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVM 120 121 CSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIG 180 181 VIPGPLEANTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA 240 241 VFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAF 300 301 NMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR |
Interface Residues: | 2, 3, 12, 13, 14, 15, 17, 18, 24, 25, 26, 49, 52, 53 |
3D-footprint Homologues: | 3oqm_C, 7ce1_D, 1efa_B, 1l1m_B, 1jft_A, 1zvv_A |
Binding Motifs: | 2pub_A CGcanACg 2puc_A CGcanACg 2pud_A CGcnnACg |
Binding Sites: | 2pub_B / 2puc_B / 2pud_B |
Publications: | Schumacher M.A, Choi K.Y, Zalkin H, Brennan R.G. Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (New York, N.Y.) 266:763-70 (1994). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.