Transcription Factor

						

			
Accessions: 2pub_A (3D-footprint 20231221), 2puc_A (3D-footprint 20231221), 2pud_A (3D-footprint 20231221)

			
Names: HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR, PURR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACP7
Length: 338
Pfam Domains:      1-46 Bacterial regulatory proteins, lacI family
   58-323 Periplasmic binding proteins and sugar binding domain of LacI family
   60-306 Periplasmic binding protein domain
  169-329 Periplasmic binding protein-like domain
Sequence: 
(in bold interface residues)		   1 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSI   60
  61 GLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVM  120
 121 CSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIG  180
 181 VIPGPLEANTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA  240
 241 VFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAF  300
 301 NMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR
Interface Residues: 2, 3, 12, 13, 14, 15, 17, 18, 24, 25, 26, 49, 52, 53
3D-footprint Homologues: 1efa_B, 3oqm_C, 7ce1_D, 1l1m_B, 1zvv_A, 1jft_A
Binding Motifs: 2pub_A CGcanACg
2puc_A CGcanACg
2pud_A CGcnnACg
Binding Sites: 2pub_B / 2puc_B / 2pud_B
			
Publications: Schumacher M.A, Choi K.Y, Zalkin H, Brennan R.G. Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (New York, N.Y.) 266:763-70 (1994). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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