Transcription Factor
| Accessions: | UP00224A (UniPROBE 20160601), P26367 (JASPAR 2024), P63015 (JASPAR 2024) |
| Names: | 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Oculorhombin, paired box gene 6, Paired box protein Pax-6, Pax6, Sey, Aniridia type II protein, PAX6_HUMAN, PAX6_MOUSE |
| Organisms: | Mus musculus, Homo sapiens |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | paired box gene 6 |
| Length: | 422 |
| Pfam Domains: | 4-128 'Paired box' domain 212-267 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRY 60 61 YETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSV 120 121 SSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQ 180 181 EGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFAR 240 241 ERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIP 300 301 QPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPT 360 361 SPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPR 420 421 LQ |
| Interface Residues: | 17, 49, 50, 52, 54, 55, 71, 74, 77, 119, 120, 121, 122, 124, 125, 128, 190, 193, 194, 197, 211, 212, 213, 214, 252, 253, 255, 256, 259, 260, 263, 264, 266, 267, 270 |
| 3D-footprint Homologues: | 6pax_A, 1pdn_C, 1k78_A, 5zfz_A, 3d1n_M, 6a8r_A, 2h1k_B, 1fjl_B, 1puf_A, 3cmy_A, 1ig7_A, 6m3d_C, 1jgg_B, 1zq3_P, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 6es3_K, 7q3o_C, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 5hod_A, 3l1p_A, 1au7_A, 3a01_E, 7psx_B, 5jlw_D, 1b72_A, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1du0_A, 1o4x_A, 1le8_B, 8g87_X, 1k61_B, 4qtr_D, 1mnm_C |
| Binding Motifs: | UP00224A_1 TrayTAATTArtkvac MA0069.1 TTyACGCwTsAvTk PH0132.1 TrayTAATTArtkvac |
| Binding Sites: | AAATTAAT AATAATTA AATTAATC AATTAATG AATTAATT ACTAATTA ATAATTAA ATAATTAG ATCAATTA ATTAATTA ATTAATTC ATTAATTG CCAATTAA CTAATTAA CTAATTAG GATTAATC GCTAATTA GTTAATTA TCAATTAA TTAATTAA MA0069.1.1 MA0069.1.10 MA0069.1.11 MA0069.1.12 MA0069.1.13 MA0069.1.14 MA0069.1.15 MA0069.1.16 MA0069.1.17 MA0069.1.18 / MA0069.1.19 MA0069.1.2 / MA0069.1.3 / MA0069.1.4 / MA0069.1.5 MA0069.1.20 MA0069.1.6 / MA0069.1.7 / MA0069.1.8 / MA0069.1.9 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Epstein J., Cai J., Glaser T., Jepeal L., Maas R. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269:8355-8361 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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