Transcription Factor
| Accessions: | UP00599B (UniPROBE 20160601) |
| Names: | EKLF, Erythroid krueppel-like transcription factor, HBFQTL6, INLU, KLF1_E325K, Krueppel-like factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Krueppel-like factor 1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin level |
| Length: | 99 |
| Pfam Domains: | 16-40 Zinc finger, C2H2 type 17-40 C2H2-type zinc finger 32-54 Zinc-finger double domain 46-70 C2H2-type zinc finger 46-70 Zinc finger, C2H2 type 63-87 Zinc-finger double domain 76-98 C2H2-type zinc finger 76-98 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 SKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARS 60 61 DKLTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL |
| Interface Residues: | 1, 5, 7, 10, 14, 28, 29, 30, 31, 32, 34, 35, 37, 38, 41, 58, 59, 60, 61, 62, 63, 64, 65, 66, 69, 86, 87, 88, 89, 90, 91, 92, 93, 94, 97 |
| 3D-footprint Homologues: | 7ysf_A, 7w1m_H, 8ssu_A, 5kkq_D, 6jnm_A, 3uk3_C, 1tf3_A, 6ml4_A, 5v3j_F, 7n5w_A, 2i13_A, 1llm_D, 1ubd_C, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 5und_A, 2kmk_A, 2gli_A, 1g2f_F, 6blw_A, 1tf6_A, 6u9q_A, 5yel_A, 8h9h_G, 7eyi_G, 6e94_A, 2lt7_A, 7y3m_I, 6a57_A, 2jpa_A, 5k5i_A, 8cuc_F, 7y3l_A, 7txc_E, 5kl3_A, 2wbs_A, 5yj3_D, 2drp_D, 1f2i_J, 4x9j_A, 4m9v_C, 8gn3_A |
| Binding Motifs: | UP00599B_1 rtsmcsmmCCCCCCccacgysg |
| Binding Sites: | AACCCCCC ACCCCCCC ACCCCCCG AGGGGGGA AGGGGGGG CACCCCCC CAGGGGGG CCACCCCC CCCCCCCA CCCCCCCC CCCCCCCG CCCCCCGC CCCCCCTC CGCCCCCC GCCCCCCC GGGGGGGA GGGGGGTA ATCCCCCC CCCCCCGA GGGGGGCA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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