Transcription Factor
| Accessions: | ZFP1 (SMILE-seq 1.0), Q6P2D0 (JASPAR 2024) |
| Names: | Zfp-1, ZFP1, ZFP1_HUMAN, Zinc finger protein 1 homolog, Zinc finger protein 475 |
| Organisms: | Homo sapiens |
| Libraries: | SMILE-seq 1.0 1, JASPAR 2024 2 1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q6P2D0 |
| Notes: | TF family: KRAB+C2H9 |
| Length: | 407 |
| Pfam Domains: | 8-48 KRAB box 184-206 Zinc finger, C2H2 type 184-206 C2H2-type zinc finger 184-204 C2H2-type zinc finger 201-223 Zinc-finger double domain 211-232 C2H2-type zinc finger 212-234 Zinc finger, C2H2 type 212-232 Zinc-finger of C2H2 type 212-234 C2H2-type zinc finger 226-251 Zinc-finger double domain 239-264 C2H2-type zinc finger 240-262 Zinc finger, C2H2 type 240-262 C2H2-type zinc finger 254-278 Zinc-finger double domain 267-277 C2H2-type zinc finger 268-290 Zinc finger, C2H2 type 268-290 C2H2-type zinc finger 283-305 Zinc-finger double domain 296-318 Zinc finger, C2H2 type 296-318 C2H2-type zinc finger 310-333 Zinc-finger double domain 324-346 C2H2-type zinc finger 324-346 Zinc finger, C2H2 type 324-337 C2H2-type zinc finger 341-362 Zinc-finger double domain 351-368 C2H2-type zinc finger 352-374 Zinc finger, C2H2 type 352-374 C2H2-type zinc finger 367-391 Zinc-finger double domain 379-400 C2H2-type zinc finger 380-402 Zinc finger, C2H2 type 380-402 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MNKSQGSVSFTDVTVDFTQEEWEQLDPSQRILYMDVMLENYSNLLSVEVWKADDQMERDH 60 61 RNPDEQARQFLILKNQTPIEERGDLFGKALNLNTDFVSLRQVPYKYDLYEKTLKYNSDLL 120 121 NSNRSYAGKQTDECNEFGKALLYLKQEKTHSGVEYSEYNKSGKALSHKAAIFKHQKIKNL 180 181 VQPFICTYCDKAFSFKSLLISHKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTGEKPF 240 241 ECPECGKAFTHQSNLIVHQRAHMEKKPYECSECGKTFAQKFELTTHQRIHTGERPYECNE 300 301 CAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHMRTHTGEKPYECTECGKT 360 361 FSQRSTLRLHLRIHTGEKPYECSECGKAFSRKSRLSVHQRVHIGEKP |
| Interface Residues: | 115, 117, 121, 142, 163, 166, 167, 168, 170, 173, 177, 195, 197, 198, 201, 223, 224, 225, 226, 228, 229, 230, 250, 251, 252, 253, 254, 255, 256, 257, 258, 279, 280, 281, 282, 284, 285, 288, 289, 306, 307, 308, 309, 310, 312, 313, 315, 316, 319, 324, 333, 334, 335, 336, 337, 338, 341, 345, 362, 363, 364, 365, 366, 367, 368, 369, 390, 391, 392, 393, 394, 396, 397, 400 |
| 3D-footprint Homologues: | 7w1m_H, 8ssq_A, 8ssu_A, 6blw_A, 5kl3_A, 5k5i_A, 2drp_D, 4x9j_A, 1g2f_F, 5v3j_F, 4m9v_C, 5k5l_F, 7txc_E, 7ysf_A, 5yel_A, 6a57_A, 5kkq_D, 1tf6_A, 5ei9_F, 2lt7_A, 6e94_A, 6u9q_A, 6ml4_A, 2jpa_A, 1ubd_C, 2kmk_A, 1tf3_A, 7n5w_A, 6jnm_A, 3uk3_C, 2gli_A, 8h9h_G, 8cuc_F, 7y3l_A, 1f2i_J, 2wbs_A, 8gn3_A, 5yj3_D, 1llm_D, 7y3m_I |
| Binding Motifs: | ZFP1_1 GGwTAGTTKdGywGG ZFP1_2 rgyTGGGTATarwAc UN0151.1 cTtttATACCCWGCy UN0151.2 TtttATACCCWGC |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.