Transcription Factor

						

			
Accessions: NFIB (HT-SELEX2 May2017)

			
Names: ENSG00000147862, NFIB
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: NFI experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: NFI experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 570
Pfam Domains:      5-47 Nuclear factor I protein pre-N-terminus
   70-171 MH1 domain
  209-498 CTF/NF-I family transcription modulation region
Sequence: 
(in bold interface residues)		   1 MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE   60
  61 LLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC  120
 121 LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL  180
 181 AYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP  240
 241 IGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGS  300
 301 RTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTP  360
 361 PPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSG  420
 421 QVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASPTATTYTASGTSQA  480
 481 NRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQV  540
 541 SNRTPILPANVQNYGLNIIGEPFLQAETSN
Interface Residues: 40, 43, 44, 48
3D-footprint Homologues: 2lkx_A
Binding Motifs: NFIB_2 stTGGCrbsgtGCCArs
NFIB_methyl_1 sTTGGCryggTGCCArs
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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