Transcription Factor
| Accessions: | MEIS2_DBD (HumanTF 1.0), MEIS2_TF1 (HumanTF2 1.0), MEIS2 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Meis2, Meis1-related protein 1, MEIS2, MEIS2_HUMAN, ENSG00000134138 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O14770 |
| Notes: | Ensembl ID: ENSG00000134138; DNA-binding domain sequence; TF family: homeodomain+MEIS; Clone source: MGC, Ensembl ID: ENSG00000134138; Construct type: TF1(SBP); TF family: HomeodomainTALE; Clone source: Jolma et al. 2013, TF family: MEIS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: MEIS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 367 |
| Pfam Domains: | 266-321 Homeobox domain 282-321 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 GMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDA 60 61 LKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRA 120 121 EKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDER 180 181 DGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQG 240 241 DGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQL 300 301 AQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLD 360 361 GQQHMGI |
| Interface Residues: | 264, 265, 267, 268, 312, 313, 316, 317, 318, 320, 321 |
| 3D-footprint Homologues: | 4j19_B, 6fqp_B, 1puf_B, 2d5v_B, 1le8_A, 7q3o_C, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 4xrs_G, 3rkq_B, 5hod_A, 6fqq_E, 1le8_B, 5zfz_A, 3cmy_A, 1fjl_B |
| Binding Motifs: | MEIS2_DBD_1 wTGACAGsTGTCAm MEIS2_DBD_2 tTGACAGs MEIS2_HOXA13 CTCGTAAAmCTGTCA MEIS2_ONECUT2_1 kTGACAGcwAATCrATas MEIS2_ONECUT2_2 wTGACAgawAATCGATAm MEIS2_2 TGACAgcTGTCA MEIS2_4 TGACAssTGTCA MEIS2_methyl_1 yGACAssYGtCa MEIS2_methyl_3 TGACAssTGTCA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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