Transcription Factor

Accessions: 6wc2_M (3D-footprint 20231221)
Names: Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P52952
Length: 54
Pfam Domains: 1-54 Homeobox domain
Sequence:
(in bold interface residues)
1 RVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKSKR
Interface Residues: 1, 39, 40, 42, 43, 46, 47, 50, 51, 54
3D-footprint Homologues: 3lnq_A, 2lkx_A, 1jgg_B, 3cmy_A, 2hdd_A, 1nk2_P, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 6a8r_A, 1au7_A, 3d1n_M, 2hos_A, 7q3o_C, 1fjl_B, 5jlw_D, 2h1k_B, 6es3_K, 1b72_A, 4xrs_G, 2ld5_A, 1puf_A, 1ig7_A, 5zfz_A, 3a01_E, 6m3d_C, 5flv_I, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 4j19_B, 2h8r_B, 1puf_B, 8g87_X, 5zjt_E, 4qtr_D, 1zq3_P, 1k61_B, 4xrm_B, 1o4x_A, 4cyc_A, 3l1p_A, 1mnm_C, 1du0_A
Binding Motifs: 6wc2_CDM GCTAnnnnnaGAAAAngC
Binding Sites: 6wc2_G
6wc2_H
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]
Related annotations: PaperBLAST

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