Transcription Factor
| Accessions: | UP00618B (UniPROBE 20160601) |
| Names: | class 6, POU domain, POU6F2_E639K, Retina-derived POU domain factor 1, RPF-1, RPF1, transcription factor 2, WT5, WTSL |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | POU domain, class 6, transcription factor 2: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This g |
| Length: | 218 |
| Pfam Domains: | 18-65 Pou domain - N-terminal to homeobox domain 100-126 Pou domain - N-terminal to homeobox domain 148-203 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQS 60 61 AICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLER 120 121 WMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTKI 180 181 AEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPATAV |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 99, 100, 106, 110, 148, 149, 150, 151, 189, 190, 192, 193, 196, 197, 200, 201, 204 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 8g87_X, 1o4x_A, 3cmy_A, 5zjt_E, 1fjl_B, 6a8r_A, 1ig7_A, 6fqp_B, 5zfz_A, 1puf_A, 1nk2_P, 1zq3_P, 2lkx_A, 4cyc_A, 5jlw_D, 2ld5_A, 4xrs_G, 2h1k_B, 3rkq_B, 2r5y_A, 1puf_B, 5hod_A, 2hdd_A, 1b72_A, 3a01_E, 2d5v_B, 1jgg_B, 3lnq_A, 1le8_A, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00618B_1 wyhcgrgcTAATTAkcycarwaw |
| Binding Sites: | ACTAATTA AGTAATTA ATAATGAG ATAATTAC ATAATTAG ATAATTAT ATTAATTA CATAATTA CCTAATTA CCTCATTA CTAATTAA CTAATTAC CTAATTAG CTCATTAC CTTAATTA GATAATGA GATAATTA GCTAATTA GTTAATTA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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