Transcription Factor
| Accessions: | UP00029A (UniPROBE 20160601) |
| Names: | GTF2D, GTF2D1, HDL4, MGC117320, MGC126054, MGC126055, SCA17, TATA sequence-binding protein, TATA-binding factor, TATA-box factor, TATA-box-binding protein, TBP, Transcription initiation factor TFIID TBP subunit |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | TATA-box-binding protein: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved protein |
| Length: | 115 |
| Pfam Domains: | 18-100 Transcription factor TFIID (or TATA-binding protein, TBP) |
| Sequence: (in bold interface residues) | 1 MTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIR 60 61 EPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVG |
| Interface Residues: | 22, 24, 52, 53, 67, 69, 75, 77, 111, 112, 114 |
| 3D-footprint Homologues: | 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D, 6cnb_R, 1cdw_A, 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G |
| Binding Motifs: | UP00029A_1 yywwwwTATAwwwmta UP00029A_2 ccswtwwaasskabc |
| Binding Sites: | AAATATAT AATATATA AATATATT ATATAAAT ATATATAC ATATATAG ATATATAT ATATATTA ATATATTG ATTATAAA ATTATATA CATATATA CTTATATA GATATATA TAAATATA TATAAATA TATATAAA TATATATA TATTTAAA TTATATAA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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