Transcription Factor
| Accessions: | MEIS1_MOUSE (HOCOMOCO 10), Q60954 (JASPAR 2024) |
| Names: | Homeobox protein Meis1, MEIS1_MOUSE, Myeloid ecotropic viral integration site 1 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 390 |
| Pfam Domains: | 275-329 Homeobox domain 290-329 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMA 60 61 PSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNED 120 121 IAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGK 180 181 MPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHS 240 241 GDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYP 300 301 SEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVM 360 361 DGQQHMGIRAPGPMSGMGMNMGMEGQWHYM |
| Interface Residues: | 273, 275, 276, 320, 321, 324, 325, 326, 328, 329 |
| 3D-footprint Homologues: | 6fqp_B, 1puf_B, 2d5v_B, 7q3o_C, 1le8_A, 4j19_B, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 6a8r_A, 3lnq_A, 1k61_B, 4xrs_G, 3rkq_B, 5hod_A, 6fqq_E, 1le8_B, 5zfz_A |
| Binding Motifs: | MA0498.1 asCTGTCAstcwscy MEIS1_MOUSE.H10MO.C|M01208 TGACAGbTTwahg PH0102.1 wasbAsCTGTCAWwac |
| Binding Sites: | MA0498.1.1 MA0498.1.10 MA0498.1.11 MA0498.1.12 MA0498.1.13 MA0498.1.14 MA0498.1.15 MA0498.1.16 MA0498.1.17 MA0498.1.18 MA0498.1.19 MA0498.1.2 MA0498.1.20 MA0498.1.3 MA0498.1.4 MA0498.1.5 MA0498.1.6 MA0498.1.7 MA0498.1.8 MA0498.1.9 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Chang C. P., Jacobs Y., Nakamura T., Jenkins N. A., Copeland N. G., Cleary M. L. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins.. Mol. Cell. Biol. 17:5679-5687 (1997). [Pubmed] |
| Related annotations: | PaperBLAST |
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