Transcription Factor

Accessions: 1qpz_A (3D-footprint 20231221)
Names: HTH-type transcriptional repressor PurR, Pur regulon repressor, PURINE NUCLEOTIDE SYNTHESIS REPRESSOR, PURR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACP7
Length: 339
Pfam Domains: 2-47 Bacterial regulatory proteins, lacI family
59-324 Periplasmic binding proteins and sugar binding domain of LacI family
61-307 Periplasmic binding protein domain
170-330 Periplasmic binding protein-like domain
Sequence:
(in bold interface residues)
1 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKS 60
61 IGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLV 120
121 MCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREI 180
181 GVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 240
241 AVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETA 300
301 FNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR
Interface Residues: 3, 4, 13, 14, 15, 16, 18, 19, 25, 26, 27, 50, 53, 54
3D-footprint Homologues: 1efa_B, 3oqm_C, 7ce1_D, 1l1m_B, 1zvv_A, 1jft_A
Binding Motifs: 1qpz_A CGcanACg
Binding Sites: 1qpz_M
Publications: Glasfeld A, Koehler A.N, Schumacher M.A, Brennan R.G. The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. Journal of molecular biology 291:347-61 (1999). [Pubmed]
Related annotations: PaperBLAST

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