Transcription Factor
| Accessions: | UP00128A (UniPROBE 20160601) |
| Names: | 9430075J19Rik, A230098E07Rik, Brain-2, Brain-specific homeobox/POU domain protein 2, Brn-2, Brn2, class 3, Nervous system-specific octamer-binding transcription factor N-Oct-3, Otf7, POU domain, Pou3f2, Protein Brn-2, transcription factor 2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P31360 |
| Description: | POU domain, class 3, transcription factor 2 |
| Length: | 185 |
| Pfam Domains: | 17-90 Pou domain - N-terminal to homeobox domain 109-165 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQT 60 61 TICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVK 120 121 GALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVY 180 181 GGSRD |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 70, 74, 107, 109, 110, 111, 112, 150, 151, 153, 154, 157, 158, 161, 162, 165 |
| 3D-footprint Homologues: | 3l1p_A, 7u0g_M, 3d1n_M, 2xsd_C, 1o4x_A, 7xrc_C, 1e3o_C, 8g87_X, 1au7_A, 3lnq_A, 1fjl_B, 6a8r_A, 1puf_A, 1ig7_A, 3cmy_A, 5zfz_A, 2h1k_B, 2lkx_A, 1zq3_P, 1jgg_B, 1nk2_P, 5hod_A, 3a01_E, 3rkq_B, 2r5y_A, 2ld5_A, 5jlw_D, 7q3o_C, 1le8_A, 4cyc_A, 1b72_A, 4qtr_D, 1mnm_C, 1du0_A, 6es3_K, 4xrs_G, 7psx_B, 5flv_I, 1k61_B, 5zjt_E |
| Binding Motifs: | UP00128A_1 swtAaTTAATTArkkyr |
| Binding Sites: | AAATTAAT AATAATTA AATTAATA AATTAATT ACTAATTA ATAATGAG ATAATTAA ATAATTAG ATTAATTA CATAATTA CCTCATTA CTAATTAA CTAATTAG CTCATTAA CTTAATTA GCTAATTA GTTAATTA TAATTAAA TAATTAGA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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