Transcription Factor
| Accessions: | NFYC_HUMAN (HOCOMOCO 10), Q13952 (JASPAR 2024) |
| Names: | CAAT box DNA-binding protein subunit C, NF-YC, NFYC_HUMAN, Nuclear transcription factor Y subunit C, Nuclear transcription factor Y subunit gamma, Transactivator HSM-1/2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 458 |
| Pfam Domains: | 38-105 Core histone H2A/H2B/H3/H4 42-105 Histone-like transcription factor (CBF/NF-Y) and archaeal histone |
| Sequence: (in bold interface residues) | 1 MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKM 60 61 ISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPR 120 121 DELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII 180 181 AQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIP 240 241 VQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQGQRNASQGKPRRCLKETLQITQTE 300 301 VQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAG 360 361 ASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGMTSLSPLHPSQQ 420 421 LYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD |
| Interface Residues: | 46, 49, 53, 60, 63, 95, 140 |
| 3D-footprint Homologues: | 6r2v_B, 6r2v_C, 4awl_B, 4g92_B, 7cvo_A, 5o9g_G, 5gt0_C, 7lyc_G, 6k1k_C, 3x1t_G, 7jzv_N, 6pwe_G, 7lya_G, 6t7a_C, 5z23_C, 6px1_C, 7lyb_G, 6yov_C, 6iy2_G, 1kx5_G, 7e9c_G, 7cvo_B, 7cvq_F |
| Binding Motifs: | NFYC_HUMAN.H10MO.B|M01370 yagCCAATsasvgs MA1644.1 rrCCAATCAsa MA1644.2 CCAATCA |
| Binding Sites: | MA1644.2.13 / MA1644.2.14 / MA1644.2.18 / MA1644.2.19 / MA1644.2.2 MA1644.1.1 MA1644.1.19 MA1644.1.18 MA1644.1.2 MA1644.1.3 MA1644.1.7 MA1644.1.13 / MA1644.1.17 MA1644.1.10 / MA1644.1.8 MA1644.1.11 / MA1644.1.9 MA1644.1.12 MA1644.1.10 / MA1644.1.13 MA1644.1.14 / MA1644.1.16 MA1644.1.15 MA1644.1.14 / MA1644.1.18 MA1644.1.16 / MA1644.1.19 MA1644.1.17 / MA1644.1.20 MA1644.1.4 MA1644.1.5 MA1644.1.6 MA1644.1.8 MA1644.1.9 MA1644.1.11 MA1644.1.12 MA1644.1.15 MA1644.1.20 MA1644.2.1 / MA1644.2.10 / MA1644.2.16 / MA1644.2.9 MA1644.2.11 MA1644.2.12 / MA1644.2.6 MA1644.2.15 MA1644.2.17 MA1644.2.20 / MA1644.2.5 MA1644.2.3 / MA1644.2.4 MA1644.2.7 MA1644.2.8 |
| Publications: | Peng Y, Jahroudi N. The NFY transcription factor functions as a repressor and activator of the von Willebrand factor promoter. Blood 99:2408-17 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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