Transcription Factor
| Accessions: | Q5VIY5 (JASPAR 2024) |
| Names: | ZN468_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q5VIY5 |
| Length: | 522 |
| Pfam Domains: | 8-48 KRAB box 230-253 Zinc-finger double domain 244-253 C2H2-type zinc finger 258-282 Zinc-finger double domain 270-293 C2H2-type zinc finger 271-293 C2H2-type zinc finger 271-293 Zinc finger, C2H2 type 288-310 Zinc-finger double domain 298-319 C2H2-type zinc finger 299-321 C2H2-type zinc finger 299-321 Zinc finger, C2H2 type 299-319 Zinc-finger of C2H2 type 313-338 Zinc-finger double domain 326-342 C2H2-type zinc finger 327-349 Zinc finger, C2H2 type 342-365 Zinc-finger double domain 354-375 C2H2-type zinc finger 355-377 Zinc finger, C2H2 type 355-375 C2H2-type zinc finger 370-394 Zinc-finger double domain 382-402 C2H2-type zinc finger 383-402 Zinc-finger of C2H2 type 383-405 Zinc finger, C2H2 type 383-405 C2H2-type zinc finger 397-422 Zinc-finger double domain 410-431 C2H2-type zinc finger 411-433 C2H2-type zinc finger 411-433 Zinc finger, C2H2 type 425-448 Zinc-finger double domain 438-452 C2H2-type zinc finger 439-461 C2H2-type zinc finger 439-459 Zinc-finger of C2H2 type 439-461 Zinc finger, C2H2 type 453-477 Zinc-finger double domain 466-489 C2H2-type zinc finger 467-489 C2H2-type zinc finger 467-489 Zinc finger, C2H2 type 483-505 Zinc-finger double domain 494-517 C2H2-type zinc finger 495-515 C2H2-type zinc finger 495-517 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMLKTLSS 60 61 TGQGNTEVIHTGTLHRQASHHIGEFCFHEIEKDIHGFEFQWKEDETNGHAAPMTEIKELA 120 121 GSTGQHDQRHAGNKRIKDQLGSSFHLHLPEPHIFQSEGKIGNQVEKSINNASSVSTSQRI 180 181 CCRPKTHISNKYGNNSLHSSLLTQKWEVHMREKSFECIQSFKSFNCSSLLKKHQIIHLEE 240 241 KQCKCDVCGKVFNQKRYLACHRRCHTGEKPYKCNECGKTFGHNSSLFIHKALHTGEKPYE 300 301 CEECDKVFSRKSHLERHKRIHTGEKPYKCKVCDEAFAYNSYLAKHTILHTGEKPYTCNEC 360 361 GKVFNRLSTLARHHRLHTGEKPYKCEECDKVFSRKSHLERHRRIHSGEKPYKCEECCKVF 420 421 SRKSNLERHRRIHTGEKPYKCKVCDKAFQRDSHLAQHQRVHTGEKPYKCNECGKTFGQTS 480 481 SLIIHRRLHTGEKPYKCNECGKTFSQMSSLVYHHRLHSGEKP |
| Interface Residues: | 254, 256, 260, 265, 277, 279, 281, 282, 284, 285, 286, 288, 292, 293, 298, 300, 309, 310, 311, 312, 313, 315, 316, 320, 321, 322, 324, 326, 327, 337, 338, 339, 340, 341, 343, 344, 348, 365, 366, 367, 368, 369, 371, 372, 373, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 406, 421, 422, 423, 424, 425, 428, 430, 431, 439, 449, 450, 451, 452, 453, 456, 462, 476, 477, 478, 479, 480, 481, 482, 484, 488, 505, 506, 507, 508, 509, 511, 512, 516 |
| 3D-footprint Homologues: | 7w1m_H, 1i3j_A, 8ssq_A, 2gli_A, 1tf6_A, 6ml4_A, 5k5i_A, 8ssu_A, 5v3j_F, 4x9j_A, 5kkq_D, 5kl3_A, 1g2f_F, 5yj3_D, 2lt7_A, 5und_A, 7eyi_G, 7ysf_A, 1ubd_C, 1tf3_A, 2i13_A, 6u9q_A, 2drp_D, 4m9v_C, 5yel_A, 6blw_A, 1mey_C, 6wmi_A, 6e94_A, 2jpa_A, 5k5l_F, 8gn3_A, 2wbs_A, 1f2i_J, 5ei9_F, 2kmk_A, 6jnm_A, 7n5w_A, 1llm_D, 8h9h_G, 6a57_A, 8cuc_F, 7y3l_A, 3uk3_C, 7txc_E, 7y3m_I |
| Binding Motifs: | UN0327.1 scrCCCCCTCCCys UN0327.2 CCCCCTCCC |
| Binding Sites: | UN0327.1.1 UN0327.1.10 UN0327.1.11 / UN0327.1.9 UN0327.1.10 / UN0327.1.12 UN0327.1.11 / UN0327.1.13 UN0327.1.12 / UN0327.1.14 UN0327.1.14 / UN0327.1.15 UN0327.1.15 / UN0327.1.16 UN0327.1.16 / UN0327.1.17 UN0327.1.18 UN0327.1.18 / UN0327.1.19 UN0327.1.2 UN0327.1.19 / UN0327.1.20 UN0327.1.3 UN0327.1.3 / UN0327.1.4 UN0327.1.4 / UN0327.1.5 UN0327.1.5 / UN0327.1.6 UN0327.1.7 UN0327.1.6 / UN0327.1.8 UN0327.1.7 / UN0327.1.9 UN0327.1.13 UN0327.1.17 UN0327.1.20 UN0327.1.8 UN0327.2.11 UN0327.2.1 / UN0327.2.3 UN0327.2.10 / UN0327.2.12 / UN0327.2.14 / UN0327.2.18 / UN0327.2.19 / UN0327.2.4 / UN0327.2.5 / UN0327.2.6 / UN0327.2.7 UN0327.2.13 UN0327.2.15 UN0327.2.16 UN0327.2.17 UN0327.2.2 UN0327.2.20 UN0327.2.8 UN0327.2.9 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.