Transcription Factor
| Accessions: | THA_HUMAN (HOCOMOCO 10), P10827 (JASPAR 2024) |
| Names: | c-erbA-1, c-erbA-alpha, EAR-7, Nuclear receptor subfamily 1 group A member 1, THA_HUMAN, Thyroid hormone receptor alpha, V-erbA-related protein 7 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 490 |
| Pfam Domains: | 52-121 Zinc finger, C4 type (two domains) 209-358 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60 61 TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360 361 PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 420 421 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC 480 481 EDLAGNAASP |
| Interface Residues: | 61, 62, 64, 65, 71, 72, 74, 75, 78, 79, 105, 129, 131, 134, 136, 155, 157 |
| 3D-footprint Homologues: | 6fbq_A, 6l6q_B, 7wnh_D, 1a6y_A, 1lo1_A, 3g9m_B, 4oln_B, 2a66_A, 8hbm_B, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 7xvn_C, 4iqr_B, 2han_A, 1hcq_E, 8cef_H, 5krb_G, 2han_B, 1kb2_B, 4tnt_B, 5e69_A, 4hn5_B, 8rm6_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E |
| Binding Motifs: | THA_HUMAN.H10MO.C|M01580 rGgtsayttsAGGwCAk MA1969.1 cctgTGwCCTCAyrTGACCTywcy MA1969.2 gTGwCCTCAyrTGACCTy |
| Binding Sites: | MA1969.1.1 / MA1969.1.4 MA1969.1.10 MA1969.1.11 MA1969.1.12 MA1969.1.13 MA1969.1.14 MA1969.1.15 MA1969.1.16 MA1969.1.17 MA1969.1.18 MA1969.1.19 MA1969.1.2 / MA1969.1.5 MA1969.1.20 MA1969.1.3 / MA1969.1.7 MA1969.1.14 / MA1969.1.4 MA1969.1.15 / MA1969.1.5 MA1969.1.18 / MA1969.1.6 MA1969.1.19 / MA1969.1.7 MA1969.1.8 MA1969.1.9 MA1969.1.1 MA1969.1.10 MA1969.1.11 MA1969.1.12 MA1969.1.13 MA1969.1.16 MA1969.1.17 MA1969.1.2 MA1969.1.20 MA1969.1.3 MA1969.1.6 MA1969.1.8 MA1969.1.9 MA1969.2.1 MA1969.2.10 MA1969.2.11 MA1969.2.12 MA1969.2.13 MA1969.2.14 MA1969.2.15 MA1969.2.16 MA1969.2.17 MA1969.2.18 MA1969.2.19 MA1969.2.2 MA1969.2.20 MA1969.2.3 MA1969.2.4 MA1969.2.5 MA1969.2.6 MA1969.2.7 MA1969.2.8 MA1969.2.9 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.