Transcription Factor

Accessions: 1je8_A (3D-footprint 20231221), 1je8_B (3D-footprint 20231221), 1je8_F (3D-footprint 20231221), 1zg1_A (3D-footprint 20231221), 1zg1_B (3D-footprint 20231221), 1zg1_E (3D-footprint 20231221), 1zg1_F (3D-footprint 20231221), 1zg5_A (3D-footprint 20231221), 1zg5_B (3D-footprint 20231221), 1zg5_F (3D-footprint 20231221)
Names: NARL_ECOLI, Nitrate/Nitrite Response Regulator Protein NARL
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0AF28
Length: 66
Pfam Domains: 4-48 Sigma-70, region 4
4-59 Bacterial regulatory proteins, luxR family
4-49 Sigma-70, region 4
8-47 Winged helix-turn-helix DNA-binding
Sequence:
(in bold interface residues)
1 RDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWV 60
61 HQERIF
Interface Residues: 33, 34, 35, 36, 38, 39, 40, 41, 42, 47, 48, 50, 51, 52
3D-footprint Homologues: 7ve5_B, 4m6f_A, 5w43_B, 1zlk_A, 8dq1_C, 4wuh_B, 1je8_F
Binding Motifs: 1zg1_E TACT
1je8_AB TACCnAnnnaTGGGTA
1je8_EF TaCCnAnnnnTnGGtA
1je8_F TnGGtA
1zg1_AB TACTnnTnnaTnGGTA
1zg1_EF TACCcATnnangAGTA
1zg5_AB TAmCCCtnnaGnGGtA
1zg5_EF TACCCCtnnAGGGGTA
Binding Sites: 1je8_C / 1je8_D / 1je8_G / 1je8_H
1zg1_C / 1zg1_H
1zg1_D / 1zg1_G
1zg5_C / 1zg5_D / 1zg5_G / 1zg5_H
Publications: Maris AE., Sawaya MR., Kaczor-Grzeskowiak M., Jarvis MR., Bearson SM., Kopka ML., Schroder I., Gunsalus RP., Dickerson RE. Dimerization allows DNA target site recognition by the NarL response regulator. Nat Struct Biol. 9(10):771-8 (2002). [Pubmed]

Maris AE., Kaczor-Grzeskowiak M., Ma Z., Kopka ML., Gunsalus RP., Dickerson RE. Primary and secondary modes of DNA recognition by the NarL two-component response regulator. Biochemistry. 44(44):14538-52 (2005). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.