Transcription Factor

						

			
Accessions: 5mhj_A (3D-footprint 20231221)

			
Names: Alpha-4 protein, ICP4_HHV11, Infected cell protein 4, Major viral transcription factor ICP4, Transcriptional activator IE175
Organisms: Human herpes simplex virus 1, Human herpesvirus 1 (strain 17) (HHV-1)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P08392
Length: 194
Pfam Domains:    19-191 Herpesvirus ICP4-like protein N-terminal region
Sequence: 
(in bold interface residues)		   1 LDADATSGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARRRF   60
  61 EASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACFRISG  120
 121 AARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRR  180
 181 AYAPLLARENAALT
Interface Residues: 126, 127, 164, 165, 179, 184, 187, 188
3D-footprint Homologues: 5mhj_A, 1uaa_B
Binding Motifs: 5mhj_A aCGa
5mhj_AB aCGAt
Binding Sites: 5mhj_E
5mhj_F
			
Publications: Tunnicliffe RB, Lockhart-Cairns MP, Levy C, Mould AP, Jowitt TA, Sito H, Baldock C, Sandri-Goldin RM, Golovanov AP. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Nucleic Acids Res 45:8064-8078 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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