Transcription Factor

						

			
Accessions: HLF_full (HumanTF 1.0)

			
Names: Basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, Endothelial PAS domain-containing protein 1, EPAS-1, EPAS1_HUMAN, HIF-1-alpha-like factor, HIF-2-alpha, HIF2-alpha, HLF, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, PAS domain-containing protein 2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q99814
Notes: Ensembl ID: ENSG00000108924; Full protein sequence; TF family: bZIP; Clone source: Megaman
Length: 296
Pfam Domains:   224-277 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVP   60
  61 QSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAA  120
 121 PSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPA  180
 181 DLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAK  240
 241 RSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL*
Interface Residues: 231, 232, 235, 236, 238, 239, 242, 243
3D-footprint Homologues: 2wt7_A, 6mg1_B, 1nwq_C
Binding Motifs: HLF_full yrTTAYrTAAym
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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