Transcription Factor

						

			
Accessions: GABPA_full (HumanTF 1.0)

			
Names: B2R8X4_HUMAN, cDNA, FLJ94105, highly similar to Homo sapiens GA binding protein transcription factor, alpha subunit 60kDa, GABPA
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: B2R8X4
Notes: Ensembl ID: ENSG00000154727; Full protein sequence; TF family: ETS; Clone source: hORFeome
Length: 455
Pfam Domains:    35-122 GA-binding protein alpha chain
  171-250 Sterile alpha motif (SAM)/Pointed domain
  319-401 Ets-domain
Sequence: 
(in bold interface residues)		   1 MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ   60
  61 CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV  120
 121 EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL  180
 181 GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL  240
 241 WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP  300
 301 RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW  360
 361 GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE  420
 421 CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN*
Interface Residues: 317, 372, 373, 375, 376, 377, 379, 380, 394
3D-footprint Homologues: 3zp5_A, 1dux_F, 8ee9_F, 4mhg_A, 8smh_F, 4uno_A, 2stt_A, 8smj_F, 7jsa_J, 3jtg_A, 4lg0_B, 1yo5_C, 4iri_A, 1awc_A, 4l18_B, 1bc8_C
Binding Motifs: GABPA_full aCCGGAAGTr
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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