Transcription Factor

Accessions: Q03923 (JASPAR 2024)
Names: Zinc finger protein 85, Zinc finger protein HPF4, Zinc finger protein HTF1, ZNF85_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q03923
Length: 595
Pfam Domains: 4-44 KRAB box
161-183 Zinc-finger double domain
174-194 C2H2-type zinc finger
189-212 Zinc-finger double domain
202-224 C2H2-type zinc finger
202-224 Zinc finger, C2H2 type
202-222 C2H2-type zinc finger
217-240 Zinc-finger double domain
229-250 C2H2-type zinc finger
230-252 C2H2-type zinc finger
230-252 Zinc finger, C2H2 type
244-268 Zinc-finger double domain
257-277 C2H2-type zinc finger
258-280 C2H2-type zinc finger
258-280 Zinc finger, C2H2 type
273-296 Zinc-finger double domain
285-306 C2H2-type zinc finger
286-308 Zinc finger, C2H2 type
286-308 C2H2-type zinc finger
301-325 Zinc-finger double domain
313-333 C2H2-type zinc finger
314-336 Zinc finger, C2H2 type
314-336 C2H2-type zinc finger
328-352 Zinc-finger double domain
341-352 C2H2-type zinc finger
342-361 C2H2-type zinc finger
342-364 Zinc finger, C2H2 type
356-381 Zinc-finger double domain
369-389 C2H2-type zinc finger
370-392 C2H2-type zinc finger
370-392 Zinc finger, C2H2 type
384-409 Zinc-finger double domain
397-417 C2H2-type zinc finger
398-420 C2H2-type zinc finger
398-420 Zinc finger, C2H2 type
413-436 Zinc-finger double domain
425-446 C2H2-type zinc finger
426-448 Zinc finger, C2H2 type
441-464 Zinc-finger double domain
453-476 C2H2-type zinc finger
454-476 C2H2-type zinc finger
454-476 Zinc finger, C2H2 type
468-492 Zinc-finger double domain
482-504 Zinc finger, C2H2 type
497-520 Zinc-finger double domain
509-530 C2H2-type zinc finger
510-532 Zinc finger, C2H2 type
510-532 C2H2-type zinc finger
525-548 Zinc-finger double domain
537-558 C2H2-type zinc finger
538-560 Zinc finger, C2H2 type
538-560 C2H2-type zinc finger
552-576 Zinc-finger double domain
565-585 C2H2-type zinc finger
566-588 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MGPLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGK 60
61 EAWSMKRHEIMVAKPTVMCSHFAQDLWPEQNIKDSFQKVTLKRYGKCRHENLPLRKGCES 120
121 MDECKMHKGGCNGLNQCLTATQSKIFQCDKYVKVAHKFSNSNRHEIRHTKKKPFKCTKCG 180
181 KSFGMISCLTEHSRIHTRVNFYKCEECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFN 240
241 QSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKCKECGKAFNRSST 300
301 LTTHRKIHTGEKPYKCEECGKAFKQSSNLTTHKIIHTGEKPYKCKKCGKAFNQSAHLTTH 360
361 EVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIH 420
421 TGEKPYKCKECEKAFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRHKKSHTEEK 480
481 PYKCEECGKGFKWPSTLTIHKIIHTGEKPYKCEECGKAFNQSSKLTKHKKIHTGEKPYTC 540
541 EECGKAFNQSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTKHKIIHTGEKLQI
Interface Residues: 213, 215, 216, 219, 241, 242, 243, 244, 247, 269, 270, 271, 272, 274, 275, 277, 278, 281, 286, 296, 297, 298, 299, 300, 303, 324, 325, 326, 327, 328, 330, 331, 335, 352, 353, 354, 355, 356, 358, 359, 381, 382, 383, 384, 387, 391, 408, 409, 410, 411, 412, 414, 415, 436, 437, 438, 439, 440, 443, 445, 446, 447, 465, 466, 467, 468, 470, 471, 477, 491, 492, 493, 494, 495, 496, 499, 503, 520, 521, 522, 523, 524, 525, 526, 527, 528, 548, 549, 550, 551, 552, 553, 555, 556, 576, 577, 578, 579, 580, 582, 583
3D-footprint Homologues: 6u9q_A, 8gn3_A, 5kl3_A, 4x9j_A, 7w1m_H, 2jpa_A, 2kmk_A, 3uk3_C, 8cuc_F, 7y3l_A, 1llm_D, 7y3m_I, 1g2f_F, 2wbs_A, 5v3j_F, 5yj3_D, 8ssq_A, 8ssu_A, 1tf6_A, 7ysf_A, 6jnm_A, 2drp_D, 6blw_A, 2lt7_A, 6a57_A, 5yel_A, 5k5i_A, 5k5l_F, 5kkq_D, 6ml4_A, 5ei9_F, 7n5w_A, 2gli_A, 8h9h_G, 6e94_A, 1ubd_C, 1tf3_A, 7txc_E, 1f2i_J, 4m9v_C
Binding Motifs: MA1720.1 / UN0240.1 amrrAGATTaCwkCAk
MA1720.2 rAGATTaCwkCA
Binding Sites: UN0240.1.1
MA1720.1.5 / UN0240.1.10
MA1720.1.6 / UN0240.1.11
MA1720.1.7 / UN0240.1.12
UN0240.1.13
MA1720.1.8 / UN0240.1.14
MA1720.1.9 / UN0240.1.15
MA1720.1.10 / UN0240.1.16
UN0240.1.17
UN0240.1.18
UN0240.1.19
UN0240.1.2
UN0240.1.20
MA1720.1.1 / UN0240.1.3
MA1720.1.2 / UN0240.1.4
UN0240.1.5
MA1720.1.3 / UN0240.1.6
UN0240.1.7
MA1720.1.4 / UN0240.1.8
UN0240.1.9
MA1720.1.11
MA1720.1.12
MA1720.1.13
MA1720.1.14
MA1720.1.15
MA1720.1.16
MA1720.1.17
MA1720.1.18
MA1720.1.19
MA1720.1.20
MA1720.2.1
MA1720.2.10 / MA1720.2.12 / MA1720.2.14 / MA1720.2.16 / MA1720.2.17 / MA1720.2.19 / MA1720.2.2 / MA1720.2.3 / MA1720.2.4 / MA1720.2.5 / MA1720.2.6 / MA1720.2.7 / MA1720.2.8 / MA1720.2.9
MA1720.2.11
MA1720.2.13
MA1720.2.15
MA1720.2.18
MA1720.2.20
Publications: Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.