Transcription Factor
| Accessions: | UP00290A (UniPROBE 20160601) |
| Names: | AMY1, ANT1, BOR2, CYH3, NRA2, Pdr1, Pleiotropic drug resistance protein 1, SMR2, TIL1, TPE1, TPE3, Transcription factor PDR1, YGL013C |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P12383 |
| Description: | Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance ... |
| Length: | 549 |
| Pfam Domains: | 16-49 Fungal Zn(2)-Cys(6) binuclear cluster domain 280-548 Fungal specific transcription factor domain |
| Sequence: (in bold interface residues) | 1 MGFSGKIRKPRSKVSKACDNCRKRKIKCNGKFPCASCEIYSCECTFSTRQGGARIKNLHK 60 61 TSLEGTTVQVKEETDSSSTSFSNPQRCTDGPCAVEQPTKFFENFKLGGRSSGDNSGSDGK 120 121 NDDDVNRNGFYEDDSESQATLTSLQTTLKNLKEMAHLGTHVTSAIESIELQISDLLKRWE 180 181 PKVRTKELATTKFYPNKSIETQLMKNKYCDVVHLTRYAAWSNNKKDQDTSSQPLIDEIFG 240 241 LYSPFQFLSLQGIGKCFQNYRSKSKCEIFPRTAKETIYIMLRFFDVCFHHINQGCVSIAN 300 301 PLENYLQKMNLLPSTPSSISSAGSPNTAHTKSHVALVINHLPQPFVRNITGISNSELLSE 360 361 MNNDISMFGILLKMLDMHKNSYQNFLMEITSNPSVAKNTQSIDVLQEFIHYCQAGEALIA 420 421 LCYSYYNSTLYNYVDFTCDITHLEQLLYFLDLLFWLSEIYGFEKVLNVAVHFVSRVGLSR 480 481 WEFYVGLDENFAERRRNLWWKAFYFEKTLASKLGYPSNIDDSKINCLLPKNFRDVGFLDN 540 541 RDFIENVHL |
| Interface Residues: | 11, 12, 13, 22, 24, 25, 26, 27, 39, 40 |
| 3D-footprint Homologues: | 1f5e_P, 6o19_A, 1hwt_C, 1pyi_A, 7uik_T, 3coq_A, 6gys_C, 1d66_B, 1zme_D |
| Binding Motifs: | UP00290A_1 gwrastTTCCGGAAyrywrr |
| Binding Sites: | ACGGAATA ATATTCCG ATTAAAAA ATTCCGAG ATTCCGGA ATTTCCGG CATTCCGA CCCTCCCC CCGGAACA CCGTTCCG CGGAAAAA CGGAACAA CGGAACAG CGGAATAA TTCCGAAA TTCCGGAA ACGGAACG ATTCCGAA TAACGGAA TCACGGAA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.