Transcription Factor
| Accessions: | UP00312A (UniPROBE 20160601) |
| Names: | "Fork head protein homolog 2, Fkh2, N2403, YNL068C, YNL2403C" |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P41813 |
| Description: | Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR; potential Cdc28p substrate |
| Length: | 386 |
| Pfam Domains: | 17-105 FHA domain 273-367 Fork head domain |
| Sequence: (in bold interface residues) | 1 MLSGPNWTYYVKDLEVSIGRNTDPLNSALQENSDGVKNSYRVNIDLGPAKVVSRKHAIIK 60 61 YNMNIGGWELHILGRNGAKVNFQRTHNGPNNPPIRLSSGTLLDIGGTQMMFILPDSDPVV 120 121 APICIEHLMPNLINMFGLEGNNNPLLRDIIKQSNYAKQRQLTSNQQIKGFKLYGSGGNAP 180 181 FGSGANLGPSEQGIFNNNNNSKNKNGYFTSINPNYTASTTTSNTINPQAASPQGPPNTII 240 241 AANFVDSYKSSNAYPQALDFTSDLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIY 300 301 KYISSNYAYYRFAKSGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWRISESYQQEFLNK 360 361 WNTGKVGKIRRGSSVARQLQLHMAKF |
| Interface Residues: | 270, 313, 316, 318, 319, 320, 322, 323, 324, 326, 327, 336, 343 |
| 3D-footprint Homologues: | 7yz7_A, 7yzb_A, 3l2c_A, 7vox_H, 2hdc_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 6nce_A, 3qrf_G |
| Binding Motifs: | UP00312A_1 tdwaawGTAAACAAAgrkrv |
| Binding Sites: | GTAAACAA AATAAACA AGTAAACA AGTAAATA ATAAACAA ATAAACAC ATGTTTAC CGTAAACA CTATTTAC CTGTTTAC GATAAACA GGTAAACA GTAAACAC GTAAATAA TAAACAAA TAAACACA TATAAACA TATTTACA TGTAAACA ATAAACAG |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] |
| Related annotations: | PaperBLAST |
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