Transcription Factor

						

			
Accessions: 7khb_F (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 471
Pfam Domains:      5-36 Sigma-70 factor, region 1.2
    47-78 Sigma-70, non-essential region
   77-207 Sigma-70, non-essential region
  238-308 Sigma-70 region 2 
  317-393 Sigma-70 region 3
  406-459 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 IGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDR   60
  61 VEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDTIKATAQEEILKLSEVFKQFRL  120
 121 VPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIA  180
 181 MNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVE  240
 241 ANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITR  300
 301 SIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIA  360
 361 KEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRM  420
 421 RFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLD
Interface Residues: 111, 121, 123, 124, 126, 127, 432, 433, 442, 443, 444, 445, 447, 448
3D-footprint Homologues: 3h0d_A, 3n97_A, 6ido_B, 8cyf_B
Binding Motifs: 7khb_CDF CTTGnnnnnnnnnnnnnnnnnnCTATAATGCGnCAT
7khb_F CTTGnnnnnnnnnnnnnnnnnnCTATAATGCG
Binding Sites: 7khb_X
7khb_Y
			
Publications: Shin Y, Qayyum MZ, Pupov D, Esyunina D, Kulbachinskiy A, Murakami KS. Structural basis of ribosomal RNA transcription regulation. Nat Commun 12:528 (2021). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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