Transcription Factor
| Accessions: | Lhx4_DBD (HumanTF 1.0), UP00261A (UniPROBE 20160601) |
| Names: | Lhx4, LHX4_MOUSE, LIM homeobox protein 4, LIM/homeobox protein Lhx4, Gsh-4, Gsh4 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P53776 |
| Description: | LIM homeobox protein 4 |
| Notes: | Ensembl ID: ENSMUSG00000026468; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain 31-69 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 EDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVV 60 61 QVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRS |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 5zfz_A, 8pop_A, 1puf_A, 2h1k_B, 1fjl_B, 6a8r_A, 3cmy_A, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 2ld5_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 3d1n_M, 2hos_A, 4cyc_A, 2d5v_B, 5flv_I, 3l1p_A, 3a01_E, 6ryd_F, 1au7_A, 5hod_A, 1puf_B, 2hdd_A, 2xsd_C, 7q3o_C, 1e3o_C, 1le8_A, 7xrc_C, 8g87_X, 6es3_K, 1o4x_A, 7psx_B, 1du0_A, 5zjt_E, 4qtr_D, 4xrm_B, 1nk2_P, 6wig_A |
| Binding Motifs: | UP00261A_1 kaaaCTAATTAGstwtg Lhx4_DBD yTAATTAr |
| Binding Sites: | GGTAATTA AATTAATC AATTAATT ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATTAATTA CATAATTA CCTAATTA CGTAATTA CTAATTAA CTAATTAC CTTAATTA GCTAATTA GTAATTAA GTAATTAC GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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