Transcription Factor
| Accessions: | FOXO1_DBD (HumanTF 1.0), FOXO1_TF1 (HumanTF2 1.0), FOXO1_TF2 (HumanTF2 1.0) |
| Names: | Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1, FOXO1_HUMAN, L8E9Y8_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q12778 |
| Notes: | Ensembl ID: ENSG00000150907; DNA-binding domain sequence; TF family: Forkhead; Clone source: Gene synthesis, Ensembl ID: ENSG00000150907; Construct type: TF1(SBP); TF family: Forkhead; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000150907; Construct type: TF2(3xFLAG); TF family: Forkhead; Clone source: Jolma et al. 2013 |
| Length: | 184 |
| Pfam Domains: | 60-142 Fork head domain |
| Sequence: (in bold interface residues) | 1 MALCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNL 60 61 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKF 120 121 IRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEG 180 181 AGDS |
| Interface Residues: | 72, 73, 80, 104, 105, 107, 108, 109, 111, 112, 113, 115, 116, 125, 130, 166 |
| 3D-footprint Homologues: | 4boc_A, 8vfz_O, 8bzm_E, 7vox_H, 2hdc_A, 7tdx_A, 2c6y_A, 7yzb_A, 6el8_A, 7vou_C, 7yze_A, 7cby_C, 3g73_A, 7yzg_A, 7tdw_A, 2a07_J, 7yz7_A, 8sro_B |
| Binding Motifs: | FOXO1_DBD_1 rTAAACAw FOXO1_DBD_2 rTAAACATGTTTAC FOXO1_DBD_3 tTTCCCCACACg CUX1_FOXO1 rtAAayAaaatgATCrATa ERF_FOXO1 rwmAACAGGAArks ETV5_FOXO1_1 rscGGATGtkkwb ETV5_FOXO1_2 rtmAACAGGAwrt FOXO1_ELF1_1 cagAAAACCGAAwm FOXO1_ELF1_2 kTGTTGCCGGAAgkk FOXO1_ELF1_2_3 rtmAACAGGAAgtd FOXO1_ELK1_1 rsCGGAwGTTdtk FOXO1_ELK1_2 rwmAACAGGAAGtr FOXO1_ELK1_2_3 tgttgcCGGAAGt FOXO1_ELK3_1 rcCGGAwGTkkw FOXO1_ELK3_2 rwmAACAGGAAGtr FOXO1_ETV1 rsCGGAwGttkw FOXO1_ETV4_1 rccGGAwGTkkw FOXO1_ETV4_2 rwmAACAGGAwGyr FOXO1_ETV7 vwmAACAGGAmryrcTTCCks FOXO1_FLI1 GwmAACAGGAAGTk FOXO1_HOXA10 rwmAACAycrTwAa FOXO1_HOXB13_1 vwmmACAmmcymrTaAA FOXO1_HOXB13_2 rwmAACAymrTwAA FOXO1_HOXB13_2_3 rwmaACAsymrTwAAa FOXO1_SPDEF wvccGGATGTtdw GCM1_FOXO1_1 GtmAATAmGGGyrg GCM1_FOXO1_2 gTmAATAmGGGyas |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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