Transcription Factor

Accessions: 6od3_F (3D-footprint 20231221)
Names: bHLHb19, Class B basic helix-loop-helix protein 19, Immunoglobulin transcription factor 2, ITF-2, ITF2_HUMAN, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P15884
Length: 60
Pfam Domains: 2-55 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MRRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRE 60
Interface Residues: 3, 6, 7, 9, 10, 11, 13, 14
3D-footprint Homologues: 2ypa_A, 7z5k_B, 6od3_F, 7d8t_A, 2ypa_B, 2ql2_A, 2ql2_D, 6g1l_A
Binding Motifs: 6od3_EF CACGTgnm
6od3_F CGTGna
Binding Sites: 6od3_Y / 6od3_Z
Publications: Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]
Related annotations: PaperBLAST

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