Transcription Factor
| Accessions: | 6od3_F (3D-footprint 20231221) |
| Names: | bHLHb19, Class B basic helix-loop-helix protein 19, Immunoglobulin transcription factor 2, ITF-2, ITF2_HUMAN, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P15884 |
| Length: | 60 |
| Pfam Domains: | 2-55 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MRRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRE 60 |
| Interface Residues: | 3, 6, 7, 9, 10, 11, 13, 14 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D, 7d8t_A, 6g1l_A |
| Binding Motifs: | 6od3_EF CACGTgnm 6od3_F CGTGna |
| Binding Sites: | 6od3_Y / 6od3_Z |
| Publications: | Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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