Transcription Factor
| Accessions: | 1hf0_A (3D-footprint 20231221), 1hf0_B (3D-footprint 20231221) |
| Names: | NF-A1, Oct-1, Octamer-binding protein 1, OCTAMER-BINDING TRANSCRIPTION FACTOR 1, OTF-1, PO2F1_HUMAN, POU domain, class 2, transcription factor 1 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P14859 |
| Length: | 128 |
| Pfam Domains: | 1-70 Pou domain - N-terminal to homeobox domain 71-127 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMSKLKP 60 61 LLEKWLNDAERKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFSN 120 121 RRQKEKRI |
| Interface Residues: | 22, 38, 39, 40, 41, 43, 44, 50, 54, 62, 71, 72, 73, 74, 78, 79, 82, 83, 112, 113, 115, 116, 119, 120, 123, 124, 127 |
| 3D-footprint Homologues: | 3l1p_A, 3d1n_M, 7u0g_M, 2xsd_C, 8g87_X, 1au7_A, 1o4x_A, 7xrc_C, 7xzx_N, 3q05_B, 7xzz_N, 1e3o_C, 1lq1_D, 1fjl_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 2r5y_A, 5zfz_A, 6m3d_C, 2lkx_A, 1zq3_P, 1nk2_P, 7q3o_C, 6es3_K, 5zjt_E, 3a01_E, 1b72_A, 5hod_A, 2hdd_A, 4xrs_G, 2hos_A, 2ld5_A, 5jlw_D, 1le8_A, 2d5v_B, 1k61_B, 5flv_I, 4cyc_A, 2h1k_B, 7psx_B, 3lnq_A, 4qtr_D, 1du0_A, 1jgg_B, 3rkq_B |
| Binding Motifs: | 1hf0_AB CGTTTGAAAGGCAAATG 1hf0_B TTTCAAAcG |
| Binding Sites: | 1hf0_M 1hf0_N |
| Publications: | Reményi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, Schöler H.R, Wilmanns M. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Molecular cell 8:569-80 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
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