Transcription Factor

						

			
Accessions: T044251_1.02 (CISBP 1.02)

			
Names: MECOM, T044251_1.02;
Organisms: Homo sapiens
Libraries: CISBP 1.02 1
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
Notes: family:C2H2 ZF
Length: 1003
Pfam Domains:     21-44 Zinc finger, C2H2 type
    21-45 C2H2-type zinc finger
    76-97 C2H2-type zinc finger
    76-97 Zinc finger, C2H2 type
    76-97 C2H2-type zinc finger
   89-113 Zinc-finger double domain
  103-125 C2H2-type zinc finger
  103-125 Zinc finger, C2H2 type
  117-141 Zinc-finger double domain
  131-154 C2H2-type zinc finger
  131-154 Zinc finger, C2H2 type
  131-154 C2H2-type zinc finger
  145-171 Zinc-finger double domain
  160-180 C2H2-type zinc finger
  160-182 Zinc finger, C2H2 type
  160-179 C2H2-type zinc finger
  188-210 C2H2-type zinc finger
  188-210 Zinc finger, C2H2 type
  188-210 C2H2-type zinc finger
  218-239 Zinc finger, C2H2 type
  218-238 C2H2-type zinc finger
  218-237 C2H2-type zinc finger
  719-746 BED zinc finger
  724-746 C2H2-type zinc finger
  724-746 Zinc finger, C2H2 type
  724-746 C2H2-type zinc finger
  738-762 Zinc-finger double domain
  752-775 C2H2-type zinc finger
  752-775 Zinc finger, C2H2 type
  752-767 C2H2-type zinc finger
  766-791 Zinc-finger double domain
  781-803 C2H2-type zinc finger
  781-803 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQ   60
  61 KLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIR  120
 121 HQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKH  180
 181 IHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCE  240
 241 GKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFS  300
 301 FSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKH  360
 361 PSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESD  420
 421 KEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASI  480
 481 AEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPG  540
 541 EVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKL  600
 601 TEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYL  660
 661 RPSPGFLFHPQMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKG  720
 721 KERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKP  780
 781 FKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRN  840
 841 FIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDIT  900
 901 GKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSL  960
 961 KMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQEESKA
Interface Residues: 32, 35, 38, 42, 53, 55, 56, 59, 86, 87, 88, 89, 91, 92, 94, 95, 98, 113, 114, 115, 116, 117, 120, 141, 142, 143, 144, 145, 146, 147, 148, 149, 151, 152, 170, 171, 172, 173, 174, 175, 177, 178, 199, 200, 201, 202, 205, 228, 229, 230, 231, 233, 234, 253, 255, 256, 714, 724, 734, 735, 736, 737, 738, 741, 762, 763, 764, 765, 766, 768, 769, 791, 792, 793, 794, 795, 797, 798, 802
3D-footprint Homologues: 8ssu_A, 5kkq_D, 5v3j_F, 7w1m_H, 5und_A, 1tf6_A, 6ml4_A, 8gn3_A, 2lt7_A, 2jpa_A, 5yel_A, 5ei9_F, 6wmi_A, 8ssq_A, 7eyi_G, 2i13_A, 7txc_E, 4m9v_C, 6e94_A, 6jnm_A, 8cuc_F, 5yj3_D, 6a57_A, 1ubd_C, 2kmk_A, 3uk3_C, 1tf3_A, 7y3l_A, 7n5w_A, 6u9q_A, 1mey_C, 5kl3_A, 7ysf_A, 1f2i_J, 5k5i_A, 2gli_A, 1g2f_F, 4x9j_A, 1llm_D, 6blw_A, 8h9h_G, 7y3m_I, 2wbs_A, 2drp_D, 5k5l_F
Binding Motifs: M3225_1.02 wGAyAAGATAAGATAA
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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