Transcription Factor
| Accessions: | P50458 (JASPAR 2024) |
| Names: | Homeobox protein LH-2, LHX2_HUMAN, LIM homeobox protein 2, LIM/homeobox protein Lhx2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P50458 |
| Length: | 406 |
| Pfam Domains: | 53-110 LIM domain 115-170 LIM domain 257-319 Homeobox KN domain 267-323 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPSISSDRAALCAGCGGKI 60 61 SDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHL 120 121 GISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAH 180 181 FNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQKGRPRKRKSPGPGADLAAY 240 241 NAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLA 300 301 QKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSP 360 361 SSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQTTLTNLF |
| Interface Residues: | 266, 267, 268, 269, 270, 308, 309, 311, 312, 315, 316, 319, 320, 322, 323, 333, 336 |
| 3D-footprint Homologues: | 3d1n_M, 1puf_A, 5zfz_A, 2h1k_B, 6fqp_B, 1fjl_B, 3cmy_A, 1ig7_A, 6a8r_A, 1jgg_B, 3lnq_A, 2lkx_A, 2r5y_A, 1zq3_P, 1nk2_P, 6m3d_C, 6es3_K, 2ld5_A, 7q3o_C, 5jlw_D, 4cyc_A, 2d5v_B, 4xrs_G, 3l1p_A, 7psx_B, 4j19_B, 3a01_E, 5flv_I, 1puf_B, 5zjt_E, 2hdd_A, 1b72_A, 5hod_A, 3rkq_B, 2hos_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1du0_A, 8g87_X, 4qtr_D, 1le8_B, 6fqq_E, 4xrm_B |
| Binding Motifs: | MA0700.1 rCTAATTArc MA0700.2 wwcCAATTAww MA0700.3 CAATTA |
| Binding Sites: | MA0700.3.18 / MA0700.3.19 / MA0700.3.2 / MA0700.3.4 MA0700.2.1 MA0700.2.10 / MA0700.2.7 MA0700.2.11 MA0700.2.12 / MA0700.2.8 MA0700.2.13 / MA0700.2.9 MA0700.2.10 / MA0700.2.14 MA0700.2.15 MA0700.2.16 MA0700.2.17 MA0700.2.11 / MA0700.2.18 MA0700.2.12 / MA0700.2.19 MA0700.2.2 MA0700.2.13 / MA0700.2.20 MA0700.2.2 / MA0700.2.3 MA0700.2.3 / MA0700.2.4 MA0700.2.5 MA0700.2.4 / MA0700.2.6 MA0700.2.7 MA0700.2.6 / MA0700.2.8 MA0700.2.9 MA0700.2.14 MA0700.2.15 MA0700.2.16 MA0700.2.17 MA0700.2.18 MA0700.2.19 MA0700.2.20 MA0700.2.5 MA0700.3.12 MA0700.3.1 / MA0700.3.10 / MA0700.3.11 / MA0700.3.13 / MA0700.3.14 / MA0700.3.15 / MA0700.3.17 / MA0700.3.20 / MA0700.3.6 / MA0700.3.7 / MA0700.3.8 / MA0700.3.9 MA0700.3.16 MA0700.3.3 MA0700.3.5 |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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