Transcription Factor
| Accessions: | O95936 (JASPAR 2024) |
| Names: | EOMES_HUMAN, Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O95936 |
| Length: | 686 |
| Pfam Domains: | 269-457 T-box |
| Sequence: (in bold interface residues) | 1 MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLS 60 61 CEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAA 120 121 AAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAP 180 181 NGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLY 240 241 GPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFL 300 301 SFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGS 360 361 HWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQ 420 421 TFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQSFFPEPF 480 481 VNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEY 540 541 TSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVF 600 601 SEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKC 660 661 EDINAEEYSKDTSKGMGGYYAFYTTP |
| Interface Residues: | 294, 433, 434, 450, 453, 454 |
| 3D-footprint Homologues: | 4a04_B, 1h6f_B, 5flv_I, 1xbr_B, 6f59_B, 2x6v_A |
| Binding Motifs: | MA0800.1 aAGGTGTGAaawh UN0307.1 mwCAGCAGGdr MA0800.2 AGGTGTGAa |
| Binding Sites: | MA0800.1.10 / UN0307.1.11 UN0307.1.1 MA0800.1.9 / UN0307.1.10 MA0800.1.11 / UN0307.1.12 MA0800.1.12 / UN0307.1.13 UN0307.1.14 UN0307.1.15 MA0800.1.13 / UN0307.1.16 UN0307.1.17 UN0307.1.18 MA0800.1.14 / UN0307.1.19 UN0307.1.2 MA0800.1.15 / UN0307.1.20 MA0800.1.2 / UN0307.1.3 UN0307.1.4 MA0800.1.3 / UN0307.1.5 MA0800.1.4 / UN0307.1.6 MA0800.1.5 / UN0307.1.7 MA0800.1.8 / UN0307.1.8 UN0307.1.9 MA0800.1.1 MA0800.1.16 MA0800.1.17 MA0800.1.18 MA0800.1.19 MA0800.1.20 MA0800.1.6 MA0800.1.7 MA0800.2.1 MA0800.2.10 / MA0800.2.14 MA0800.2.11 / MA0800.2.8 MA0800.2.12 MA0800.2.13 MA0800.2.15 / MA0800.2.17 / MA0800.2.20 MA0800.2.16 MA0800.2.18 MA0800.2.19 / MA0800.2.3 / MA0800.2.7 MA0800.2.2 / MA0800.2.4 MA0800.2.5 MA0800.2.6 MA0800.2.9 |
| Publications: | Wilson V, Conlon FL. The T-box family. Genome Biol : (2002;3(6):REVIEWS3008.). [Pubmed] |
| Related annotations: | PaperBLAST |
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