Transcription Factor
| Accessions: | UP00552A (UniPROBE 20160601) |
| Names: | LUX, LUX ARRHYTHMO, PCL1, PHYTOCLOCK 1, Transcription factor LUX |
| Organisms: | Arabidopsis thaliana |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Transcription factor LUX: Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcr |
| Length: | 323 |
| Pfam Domains: | 146-196 Myb-like DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MGEEVQMSDYDVSGDGDRVSEWEMGLPSDEDLASLSYSLIPPNLAMAFSITPERSRTIQD 60 61 VNRASETTLSSLRGGSSGPNTSSSNNNVEEEDRVGSSSPGSDSKKQKTSNGDGDDGGGVD 120 121 PDSAMAAEEGDSGTEDLSGKTLKRPRLVWTPQLHKRFVDVVAHLGIKNAVPKTIMQLMNV 180 181 EGLTRENVASHLQKYRLYLKRMQGLTNEGPSASDKLFSSTPVPPQSFQDIGGGGGSSGNV 240 241 GVPIPGAYGTQQMMQMPVYAHHMGMQGYHHQNHNHDPYHQNHRHHHGAGGNGAFESNPYM 300 301 MQQNKFGSMASYPSVGGGSANEN |
| Interface Residues: | 146, 185, 186, 189, 190, 193, 194 |
| 3D-footprint Homologues: | 6qec_A, 7d3t_D, 6j5b_C |
| Binding Motifs: | UP00552A_1 kawAGATwCGstkw UP00552A_2 kwwAGATwCGstww UP00552A_3 kmwAGATwCGswtw UP00552A_4 tbywAGATwYksyk UP00552A_5 khaAGATwYgstka UP00552A_6 kwaAGATwygstka |
| Binding Sites: | AAGATACG AAGATCTT AAGATTCG AAGATTCT AGAATATC AGATACGC AGATACGG AGATCCGC AGATCTTC AGATTCGA AGATTCGC AGATTCGG AGATTCTG ATTCTTCC CAGATTCG CGAATCTA CGTATCTA GAATATCC GCGTATCA TACGGCAA |
| Publications: | Helfer A, Nusinow DA, Chow BY, Gehrke AR, Bulyk ML, Kay SA. LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock. Curr Biol 21:126-33 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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