Transcription Factor
| Accessions: | UP00617D (UniPROBE 20160601) |
| Names: | Brain-3C, Brain-specific homeobox/POU domain protein 3C, Brn-3C, BRN3C, class 4, DFNA15, MGC138412, POU domain, POU4F3_N316K, transcription factor 3 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | POU domain, class 4, transcription factor 3: This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 200 |
| Length: | 175 |
| Pfam Domains: | 18-93 Pou domain - N-terminal to homeobox domain 112-168 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSL 60 61 SQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAA 120 121 PEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKKVVRVWFCNQRQKQKRMKYSAVH |
| Interface Residues: | 42, 43, 61, 62, 63, 64, 66, 67, 73, 77, 112, 113, 114, 115, 153, 154, 156, 157, 160, 161, 164, 165, 168 |
| 3D-footprint Homologues: | 7u0g_M, 3cro_R, 3d1n_M, 3l1p_A, 1e3o_C, 2xsd_C, 7xrc_C, 1au7_A, 8g87_X, 1o4x_A, 1puf_A, 2h1k_B, 1fjl_B, 5zfz_A, 3cmy_A, 3lnq_A, 1nk2_P, 1zq3_P, 2lkx_A, 1jgg_B, 2ld5_A, 2r5y_A, 5hod_A, 1puf_B, 7psx_B, 3a01_E, 1ig7_A, 1b72_A, 2d5v_B, 5zjt_E, 5jlw_D, 1le8_A, 7q3o_C, 6es3_K, 4qtr_D, 4xrs_G, 5flv_I |
| Binding Motifs: | UP00617D_1 thravkTTATTAATAwtktmak |
| Binding Sites: | AAATTAAT AATTAATA AATTAATG AATTAATT ATATTAAT ATTAATAA ATTAATAC ATTAATAG ATTAATGA ATTAATTA CATTAATA CATTAATG CTCATTAA TATTAATA TCATTAAA TTAATTAA AATATTTA ACATTAAT ATTAATGC ATTAATGG |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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