Transcription Factor

						

			
Accessions: 3d1n_I (3D-footprint 20231221), 3d1n_K (3D-footprint 20231221), 3d1n_M (3D-footprint 20231221), 3d1n_O (3D-footprint 20231221)

			
Names: Brain-5, Brain-specific homeobox/POU domain protein 5, Brn-5, mPOU homeobox protein, PO6F1_HUMAN, POU domain, class 6, transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q14863
Length: 150
Pfam Domains:      2-71 Pou domain - N-terminal to homeobox domain
   93-148 Homeobox domain
Sequence: 
(in bold interface residues)		   1 NMEEIREFAKNFKIRRLSLGLTQTQVGQAMTATEGPAYSQSAISRFEKLDITPKSAQKLK   60
  61 PVLEKWLNEAELRNQEGQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQ  120
 121 EITEMAKELNYDREVVRVWFSNRRQTLKNT
Interface Residues: 23, 39, 40, 41, 42, 44, 45, 51, 55, 93, 94, 95, 96, 98, 134, 135, 137, 138, 141, 142, 145, 146
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 1o4x_A, 5zjt_E, 1puf_A, 1ig7_A, 6a8r_A, 5zfz_A, 1fjl_B, 3cmy_A, 1nk2_P, 1zq3_P, 2lkx_A, 7q3o_C, 1mnm_C, 2ld5_A, 6es3_K, 2h1k_B, 1b72_A, 3rkq_B, 2r5y_A, 5hod_A, 2hdd_A, 4cyc_A, 1puf_B, 1jgg_B, 5jlw_D, 3a01_E, 3lnq_A, 6m3d_C, 4xrs_G, 1le8_A, 1du0_A, 4qtr_D, 1k61_B
Binding Motifs: 3d1n_IK ATATnnTATAnnyATAntTTAT
3d1n_M TATAnTTTAT
3d1n_MO ATAAAnTATAnnTATAnTTTAT
Binding Sites: 3d1n_C
3d1n_D
3d1n_G
3d1n_H
			
Publications: Pereira J.H, Kim S.H. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. Journal of structural biology 167:159-65 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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