Transcription Factor

						

			
Accessions: P14652 (JASPAR 2024)

			
Names: Homeobox protein Hox-2.8, Homeobox protein Hox-2H, Homeobox protein Hox-B2, HXB2_HUMAN, K8
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P14652
Length: 356
Pfam Domains:   144-200 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGA   60
  61 STLQRPRSQKRAEDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASA  120
 121 VPASGVGSPADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL  180
 181 DLTERQVKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRA  240
 241 AWEACCHPPEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQD  300
 301 SPFLPDLNFFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP
Interface Residues: 144, 145, 146, 147, 185, 186, 188, 189, 192, 193, 196, 197, 200
3D-footprint Homologues: 5zfz_A, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 6m3d_C, 1nk2_P, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4j19_B, 1ig7_A, 7psx_B, 5hod_A, 3a01_E, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1le8_A, 7xrc_C, 1au7_A, 2xsd_C, 1e3o_C, 3l1p_A, 8g87_X, 1o4x_A, 1du0_A, 4qtr_D
Binding Motifs: MA0902.1 rstmATTArc
UN0565.1 rGGTGTTAATkr
MA0902.2 symATTAs
MA0902.3 ymATTA
UN0565.2 rGGTGTTAATk
			
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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