Transcription Factor
| Accessions: | HTF4_HUMAN (HOCOMOCO 10), Q99081 (JASPAR 2024) |
| Names: | bHLHb20, Class B basic helix-loop-helix protein 20, DNA-binding protein HTF4, E-box-binding protein, HTF4_HUMAN, TCF-12, Transcription factor 12, Transcription factor HTF-4 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 682 |
| Pfam Domains: | 578-631 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSW 60 61 GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGSFSLY 120 121 SRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLHDSAALDPLQA 180 181 KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSS 240 241 SNGMSQPGFGGILGTSTSHMSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG 300 301 STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP 360 361 STPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVG 420 421 PSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNH 480 481 SVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKS 540 541 DDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKEL 600 601 GRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAVSAE 660 661 PPTTLPGTHPGLSETTNPMGHM |
| Interface Residues: | 579, 582, 583, 585, 586, 587, 589, 590 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 6g1l_A, 6od3_F, 7d8t_A, 2ql2_D, 2ypa_B, 2ql2_A |
| Binding Motifs: | HTF4_HUMAN.H10MO.B|M01233 vrsCAGGTGbg MA1648.1 ssCACCTGCys MA1648.2 CACCTGC |
| Binding Sites: | MA1648.1.19 MA1648.1.1 MA1648.1.19 MA1648.1.20 MA1648.1.10 MA1648.1.16 MA1648.1.10 / MA1648.1.4 MA1648.1.13 / MA1648.1.6 MA1648.1.11 / MA1648.1.5 MA1648.1.12 MA1648.1.14 MA1648.1.15 / MA1648.1.7 MA1648.1.16 MA1648.1.17 / MA1648.1.8 MA1648.1.18 / MA1648.1.9 MA1648.1.2 MA1648.1.3 MA1648.1.4 MA1648.1.5 MA1648.1.6 MA1648.1.7 MA1648.1.3 / MA1648.1.8 MA1648.1.9 MA1648.1.11 / MA1648.1.15 MA1648.1.12 MA1648.1.13 MA1648.1.14 MA1648.1.17 MA1648.1.18 MA1648.1.20 MA1648.2.1 / MA1648.2.13 MA1648.2.14 / MA1648.2.2 / MA1648.2.6 MA1648.2.19 MA1648.2.11 / MA1648.2.12 / MA1648.2.15 MA1648.2.16 / MA1648.2.17 MA1648.2.9 MA1648.2.5 MA1648.2.4 MA1648.2.10 / MA1648.2.20 MA1648.2.18 / MA1648.2.7 MA1648.2.3 MA1648.2.8 |
| Publications: | Doyle K, Zhang Y, Baer R, Bina M. Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins. J Biol Chem 269:12099-105 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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