Transcription Factor
| Accessions: | LHX8 (HT-SELEX2 May2017) |
| Names: | ENSG00000162624, LHX8 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Znf_LIM_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Znf_LIM_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 356 |
| Pfam Domains: | 75-131 LIM domain 136-190 LIM domain 226-282 Homeobox domain 250-279 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MQILSRCQGLMSEECGRTTALAAGRTRKGAGEEGLVSPEGAGDEDSCSSSAPLSPSSSPR 60 61 SMASGSGCPPGKCVCNSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDK 120 121 DIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALV 180 181 EEKVLCRVHYDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVM 240 241 QAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSTPVTAVPPS 300 301 RLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHSPTTLGLQPLLPHSMTQLPISHT |
| Interface Residues: | 226, 227, 228, 229, 267, 268, 270, 271, 274, 275, 277, 278, 279, 282 |
| 3D-footprint Homologues: | 1ig7_A, 5zfz_A, 1puf_A, 3d1n_M, 8ejp_B, 6a8r_A, 8pmf_A, 1fjl_B, 3cmy_A, 6m3d_C, 1jgg_B, 3lnq_A, 1zq3_P, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 4cyc_A, 2r5y_A, 8ik5_C, 5flv_I, 2hos_A, 5zjt_E, 1puf_B, 8osb_E, 7psx_B, 5hod_A, 1au7_A, 3a01_E, 5jlw_D, 3rkq_B, 8eml_B, 1b72_A, 4xrs_G, 2hdd_A, 9b8u_A, 7xrc_C, 2xsd_C, 1e3o_C, 1du0_A, 8bx1_A, 4qtr_D, 1le8_B, 4xrm_B |
| Binding Motifs: | LHX8_4 sTAATTAv LHX8_5 TrATTGCAATyA LHX8_methyl_1 cTCGTTAr LHX8_methyl_2 cTAATyAv LHX8_methyl_3 TrATTGCAATyA |
| Related annotations: | PaperBLAST |
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