Transcription Factor
| Accessions: | UP00211A (UniPROBE 20160601) |
| Names: | Brain-1, Brain-specific homeobox/POU domain protein 1, Brn-1, Brn-1 protein, Brn1, class 3, Otf8, POU domain, Pou3f3, Skin1, transcription factor 3 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P31361 |
| Description: | POU domain, class 3, transcription factor 3 |
| Length: | 185 |
| Pfam Domains: | 17-90 Pou domain - N-terminal to homeobox domain 109-165 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQT 60 61 TICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVK 120 121 GALESHFLKCPKPSAQEITNLADSLQLEKEAVRVWFCNRRQKEKRMTPPGIQQQTPDDVY 180 181 SQVGT |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 70, 74, 107, 109, 110, 111, 112, 150, 151, 153, 154, 157, 158, 161, 162, 164, 165, 171, 174 |
| 3D-footprint Homologues: | 3d1n_M, 3l1p_A, 7u0g_M, 1e3o_C, 8g87_X, 2xsd_C, 1o4x_A, 1au7_A, 7xrc_C, 3lnq_A, 2h1k_B, 1fjl_B, 6a8r_A, 1puf_A, 1ig7_A, 3cmy_A, 5zfz_A, 1nk2_P, 2lkx_A, 1zq3_P, 1jgg_B, 3rkq_B, 2r5y_A, 5hod_A, 3a01_E, 4xrs_G, 2ld5_A, 5jlw_D, 7q3o_C, 1le8_A, 7psx_B, 5flv_I, 1k61_B, 5zjt_E, 4cyc_A, 4xrm_B, 1mnm_C, 1b72_A, 6es3_K |
| Binding Motifs: | UP00211A_1 wardTATGCATAwtdwa |
| Binding Sites: | ATGCAAAT AATATGCA AATGCATA AATTAATT AATTATGC ATATGCAA ATATGCAT ATTATGCA ATTATGCG ATTATTCA CATAATTA CATGCATA CATTATGC CTGCATAA GATATGCA GCATAATA TATGCAAA TATGCATA TGCATAAA TTATGCAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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